Minimally Invasive Phototriggered Nanosystems for Advanced Theranostics of Ocular Diseases
Source abstract
Abstract
The prevalence of various ocular diseases poses a significant threat to global vision health. Conventional therapeutic strategies encounter considerable challenges, including limited bioavailability of topically administered drugs and unavoidable repeated invasive procedures for the refractory conditions. Photodynamic therapy (PDT) and photothermal therapy (PTT), known for their rapid therapeutic effects, are successfully employed to treat ocular infections and associated persistent biofilms, offering a promising alternative to conventional antibiotics. Furthermore, innovative light-activated synergistic therapeutic nanosystems are being progressively developed for the treatment of the posterior segment and refractory ocular disorders. These systems enable controlled drug release at desired intraocular sites, achieving more precise and effective treatment with minimized invasiveness. This Review highlights the cutting-edge advancements in minimally invasive in situ phototriggered nanosystems for efficient treatment of ocular disorders, offering valuable insights for the future development of intelligent optical theranostic strategies in the management of ocular diseases.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Nanoplatforms for cancer theranostics · Corneal Surgery and Treatments · Ocular Surface and Contact Lens
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Clinical Translational Research Center of Aggregation-Induced Emission, The Second Affiliated Hospital, School of Medicine, School of Science and Engineering, Guangdong Basic Research Center of Excellence for Aggregate Science, Shenzhen Institute of Aggregate Science and Technology
The Chinese University of Hong Kong, Shenzhen (CUHK-Shenzhen)
Department of Ophthalmology, Peking Union Medical College Hospital
Chinese Academy of Medical Sciences and Peking Union Medical College
Department of Chemistry, The Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, Division of Life Science, State Key Laboratory of Molecular Neuroscience, and Department of Biological and Chemical Engineering
The Hong Kong University of Science and Technology
Funding
National Key Research and Development Program of China · Science, Technology and Innovation Commission of Shenzhen Municipality · National Natural Science Foundation of China · Shenzhen Key Laboratory of Functional Aggregate Materials
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