DataVXACS Materials LettersPaper
journal article·2024-01-01

Photocatalytic Polyamine Depletion for the Treatment of Psoriasis

Ting Hu, Hui Yuan, Qianfeng He, Jie Ren, Yan Qiu, Jianqing Lin, Yuhang Li, Canzhong Lu

ACS Materials Letters· Volume 6· Issue 1
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Source abstract

Abstract

Psoriasis is an incurable autoinflammatory disorder associated with metabolic abnormalities. Excessive polyamine production in keratinocytes plays a vital role in the initiation and progression of psoriasis. In this study, we propose a new strategy to degrade polyamines and ameliorate psoriasis development based on the new type of polyoxometalate (POMs)-based silver material C 32 H 100 Ag 6 O 98 P 2 S 16 W 24 (HT-1). HT-1 possessed efficient peroxidase (POD) and oxidase (OXD)-like activities for promoting reactive oxygen species (ROS) generation under visible light (VIS) irradiation. The generated ROS from HT-1 efficiently decreased the levels of polyamines and reduced IL-17A-induced psoriatic responses in keratinocytes. Meanwhile, photocatalytic depletion of polyamines by HT-1 also reduced the endosomal self-RNA sensing in DCs, impairing the maturation and T cells priming function of DC, thereby attenuating the development of psoriasis. In summary, this study may pave the way for a promising treatment approach for psoriasis, even for other autoinflammatory diseases.
Source: openalex_inverted_index · Quality: baseline

Research context

Catalysis & surfaces

OpenAlex topics: Advanced Nanomaterials in Catalysis · Polyoxometalates: Synthesis and Applications · Nanoplatforms for cancer theranostics

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

State Key Laboratory of Structural Chemistry, Fujian Science & Technology Innovation Laboratory for Optoelectronic Information of China, and Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350108, China

Xiamen Institute of Rare-earth Materials, Chinese Academy of Sciences, Xiamen, Fujian 361005, China

Eye Institute of Xiamen University, Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, School of Medicine, Xiamen University, Xiamen 361102, China

Department of Breast and Thyroid Surgery, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian Province 362000, China

Funding

Natural Science Foundation of Xiamen Municipality · Fujian Science and Technology Innovation Laboratory for Optoelectronic Information of China · National Natural Science Foundation of China · Chinese Academy of Sciences

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