DataVXACS Materials LettersPaper
journal article·2023-09-04Open access

Activated Metals to Generate Heat for Biomedical Applications

Eva Remlova, Vivian Rachel Feig, Ziliang Kang, Ashka Patel, Ian Ballinger, Anna Ginzburg, Johannes Kuosmanen, Niora Fabian, Keiko Ishida, Joshua Jenkins, Alison Hayward, Giovanni Traverso

ACS Materials Letters· Volume 5· Issue 9
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Source abstract

Abstract

High Resolution Image Download MS PowerPoint Slide Delivering heat in vivo could enhance a wide range of biomedical therapeutic and diagnostic technologies, including long-term drug delivery devices and cancer treatments. To date, providing thermal energy is highly power-intensive, rendering it oftentimes inaccessible outside of clinical settings. We developed an in vivo heating method based on the exothermic reaction between liquid-metal-activated aluminum and water. After establishing a method for consistent activation, we characterized the heat generation capabilities with thermal imaging and heat flux measurements. We then demonstrated one application of this reaction: to thermally actuate a gastric resident device made from a shape-memory alloy called Nitinol. Finally, we highlight the advantages and future directions for leveraging this novel in situ heat generation method beyond the showcased example.
Source: openalex_inverted_index · Quality: baseline

Research context

Metals & alloys

OpenAlex topics: Advanced Sensor and Energy Harvesting Materials · Aerogels and thermal insulation · Cephalopods and Marine Biology

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Division of Gastroenterology, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts 02115, United States

Department of Health Sciences and Technology, Eidgenössische Technische Hochschule Zürich, Universitätstrasse 2, 8092 Zürich, Switzerland

The David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States

Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States

Department of Bioengineering, Northeastern University, Boston, Massachusetts 02115, United States

Department of Cell/Cellular and Molecular Biology, Northeastern University, Boston, Massachusetts 02115, United States

Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States

Funding

National Centre of Competence in Research Robotics · Nad?cie Tatra Banky · Schmidt Family Foundation · Bill and Melinda Gates Foundation

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