journal article·2021-11-01

Nanoengineered Antiviral Fibrous Arrays with Rose-Thorn-Inspired Architectures

Amir Nasajpour, Mohamadmahdi Samandari, Chandrashekhar D. Patil, Reza Abolhassani, Rahul K. Suryawanshi, Rainer Adelung, Horst-Günter Rubahn, Ali Khademhosseini, Yogendra Kumar Mishra, Deepak Shukla, Ali Tamayol, Paul S. Weiss

ACS Materials Letters· Volume 3· Issue 11
Publisher page

Abstract

Herpes simplex virus (HSV) plagues billions of humans with infections globally. We have developed and demonstrated rose-thorn-inspired antiviral fibrous arrays by electrospinning a composite of polycaprolactone (PCL) polymer with a dispersion of anisotropic zinc oxide tetrapod nanoparticles (ZOTeN). This rose-thorn-mimicking material enables physical and chemical protection. Under blue-light stimulation, ZOTeN photocatalyzes the production of hydrogen peroxide for an accessible disinfection and sterilizing mechanism to prolong materials usage. Using scanning electron microscopy and X-ray photoelectron spectroscopy, we confirm the rose-thorn-inspired morphology and the chemical composition, respectively. The fibrous material has dose-dependent antiviral properties against both HSV-1 and HSV-2. The engineered mats can potentially be used for manufacturing antiviral garments, face coverings, and bandages.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Herpesvirus Infections and Treatments · Extracellular vesicles in disease · Ocular Diseases and Behçet’s Syndrome

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

California NanoSystems Institute, University of California, Los Angeles, Los Angeles, California 90095, United States

Department of Chemistry & Biochemistry, University of California, Los Angeles, Los Angeles, California 90095, United States

Department of Biomedical Engineering, University of Connecticut, Farmington, Connecticut 06030, United States

Department of Ophthalmology and Visual Sciences, University of Illinois, Chicago, Illinois, 60612, United States

Mads Clausen Institute, NanoSYD, University of Southern Denmark, Alsion 2, Sønderborg, DK-6400, Denmark

Functional Nanomaterials, Institute for Materials Science, Kiel University, Kaiserstr. 2, 24143, Kiel, Germany

Terasaki Institute for Biomedical Innovation, Los Angeles, California 90064, United States

Department of Microbiology and Immunology, University of Illinois, Chicago, Illinois 60612, United States

Department of Materials Science and Engineering, University of California, Los Angeles, Los Angeles, California 90095, United States

Department of Bioengineering, University of California, Los Angeles, Los Angeles, California 90095, United States

Funding

U.S. Department of Health and Human Services · European Commission · Deutsche Forschungsgemeinschaft · University of Connecticut · National Institutes of Health

References (19)

Show source-provided references
1. 10.1016/S0140-6736(00)04638-910.1016/S0140-6736(00)04638-9 ↗
2. 10.1016/j.survophthal.2012.01.00510.1016/j.survophthal.2012.01.005 ↗
3. 10.1016/j.antiviral.2003.09.00610.1016/j.antiviral.2003.09.006 ↗
4. 10.1016/j.antiviral.2018.04.01610.1016/j.antiviral.2018.04.016 ↗
5. 10.1016/j.antiviral.2011.08.01710.1016/j.antiviral.2011.08.017 ↗
6. 10.1016/j.antiviral.2012.09.02010.1016/j.antiviral.2012.09.020 ↗
7. 10.1371/journal.pone.008498310.1371/journal.pone.0084983 ↗
8. 10.3389/fimmu.2019.0050010.3389/fimmu.2019.00500 ↗
9. 10.4049/jimmunol.150237310.4049/jimmunol.1502373 ↗
10. 10.1021/acs.nanolett.7b0292910.1021/acs.nanolett.7b02929 ↗
11. 10.1021/ja01108a01710.1021/ja01108a017 ↗
12. 10.1007/BF0298740910.1007/BF02987409 ↗
13. 10.1039/c3tc30775a10.1039/c3tc30775a ↗
14. 10.1021/la400378t10.1021/la400378t ↗
15. 10.1016/j.ceramint.2012.08.07510.1016/j.ceramint.2012.08.075 ↗
16. 10.3390/nano904063710.3390/nano9040637 ↗
17. 10.1021/acscatal.8b0487310.1021/acscatal.8b04873 ↗
18. 10.1021/acs.jpclett.6b0292410.1021/acs.jpclett.6b02924 ↗
19. 10.1002/adfm.20210223410.1002/adfm.202102234 ↗