DataVXACS Materials LettersPaper
journal article·2025-05-05

Superimposed Effect of Intramolecular Modular Assembling and Silver Coordination to Amplify Superoxide Anion Radical for Antitumor and Antibacterial Photodynamic therapy

Siwen Wei, Haoran Hou, Yingnan Wu, Wenlong Chen, Gaobo Hong, Dapeng Liu, Meng Zhou, Fengling Song

ACS Materials Letters· Volume 7· Issue 5
Publisher page
Source abstract

Abstract

Photodynamic therapy (PDT) calls for highly efficient photosensitizers with a Type I mechanism to overcome the limitation of the hypoxic microenvironment, which exists in both tumor tissues and bacterial infection sites. However, the rational design of Type I PDT photosensitizers is still a challenging goal. Herein, a dyad photosensitizer is developed based on an intramolecular modular assembling strategy to produce superoxide anion radical via a Type I mechanism. Further, the superoxide anion radical amplification is superimposed by silver coordination. In vitro and in vivo antitumor and antibacterial PDT experiments demonstrated the superimposed effect on superoxide anion radical amplification. This work opens a window to rationally design Type I PDT photosensitizers.
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Research context

OpenAlex topics: Nanoplatforms for cancer theranostics · Luminescence and Fluorescent Materials · Advanced Nanomaterials in Catalysis

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

State Key Laboratory of Fine Chemicals, Frontiers Science Center for Smart Materials Oriented Chemical Engineering

Dalian University of Technology

College of Materials Science and Engineering

Shenzhen University

Institute of Frontier Chemistry, School of Chemistry and Chemical Engineering

Shandong University

Department of Dermatology, Qilu Hospital (Qingdao), Cheeloo College of Medicine

Funding

Science and Technology Foundation of Shenzhen City · Basic and Applied Basic Research Foundation of Guangdong Province · China Postdoctoral Science Foundation · National Natural Science Foundation of China · Natural Science Foundation of Shandong Province

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