DataVXACS Materials LettersPaper
journal article·2025-04-07

Camouflaging Attenuated Salmonella by Detachable Metal Polyphenol Nanoshells for Enhanced Bacteria-Based Cancer Immunotherapy

Bin Zhang, Rui-Mei Jin, Xiao-Ting Xie, Lin-Fang Tan, Meng-Wen Ma, Chao-Qin Li, Yuan-Di Zhao, Qiong Wang, Jia-Hua Zou, Bo Liu

ACS Materials Letters· Volume 7· Issue 4
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Source abstract

Abstract

We developed Salmonella typhimurium VNP20009 camouflaged biodegradable metal polyphenol nanoshells for efficiently reducing bacterial virulence and prolonging bacterial in vivo circulation time to increase bacterial tumor enrichment. The four-layer nanoshell-encapsulated VNP20009 (M 4 @V) ensured the safety of treatment by effectively inhibiting bacterial proliferation and significantly reducing the toxicity in vivo. Moreover, the nanoshells significantly enhanced the biocompatibility of VNP20009 to protect it from phagocytosis, resulting in a 4-fold in vivo circulation time and a 1.97-fold increase in peak accumulation at the tumor sites. After the M 4 @V colonized in the tumor microenvironment, physiologically relevant levels of ascorbic acid (AA) triggered the degradation of the nanoshells to restore the proliferation of VNP20009 at the tumor sites. Within 4T1 tumor-bearing mouse models, the AA+M4@V showed remarkable efficacy in suppressing both primary and metastatic tumors and was accompanied by a highly specific immune response.
Source: openalex_inverted_index · Quality: baseline

Research context

NanomaterialsBiomaterials

OpenAlex topics: Cancer Research and Treatments · Nanoplatforms for cancer theranostics · Graphene and Nanomaterials Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Britton Chance Center for Biomedical Photonics at Wuhan National Laboratory for Optoelectronics - Hubei Bioinformatics & Molecular Imaging Key Laboratory, Department of Biomedical Engineering, College of Life Science and Technology

Huazhong University of Science and Technology

School of Life Science, Zhengzhou University, 100 Science Road, Zhengzhou 450001, Henan, P. R. China

School of Laboratory Medicine

Hubei University of Chinese Medicine

Cancer Center, Union Hospital

Tongji Medical College, Huazhong University of Science and Technology

Department of Oncology, Huanggang Central Hospital of Yangtze University, No.126 Qi’an Road, Huangzhou District, Huanggang 438000, Hubei, P. R. China

Funding

Outstanding Young and Middle-aged Scientific Innovation Team of Colleges and Universities of Hubei Province · Huazhong University of Science and Technology · Hubei Technological Innovation Special Fund · National Natural Science Foundation of China

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