DataVXACS Materials LettersPaper
journal article·2024-03-04

The “Inner–Outer” Molecules-Loaded Fiber-Hydrogel Scaffolds Coordinate Specific Immunity and Neural Differentiation for Repairing SCI

Wei Hu, Junchao Luo, Chichi Chen, Xinyue Wang, Junjie Niu, Hao Shen, Xiao-zhong Zhou, Jie Sun, Huilin Yang, Zheng Chen, Xingzhi Liu, Qin Shi

ACS Materials Letters· Volume 6· Issue 3
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Source abstract

Abstract

The treatment of spinal cord injury (SCI) remains unsatisfactory because of the inflammatory microenvironment and the limited potential for nerve regeneration. However, most treatments have focused on modulating nonspecific immunity and ignored the importance of specific immunity in SCI. In this study, an “Inner–Outer” Metformin (Met) and anti-CD80 monoclonal antibody (CD80 mAb)-loaded fiber-hydrogel scaffold (P/G-Met-CD80 mAb) was constructed through microsol-electrospinning and UV illumination methods. The P/G-Met-CD80 mAb scaffolds exhibited good biocompatibility and hydrophilicity, facilitating cell proliferation and adhesion. In addition, the scaffolds were capable of releasing CD80 mAb and Met sequentially, exerting their protected functions at different stages post-SCI in rats. The released CD80 mAb at an early stage significantly inhibited specific immune response by blocking T-cell costimulatory activation and reducing IL-2 secretion, improving the inflammatory microenvironment after SCI. Late stage-released Met recruited neural stem cells (NSCs) to the injury area and enhanced NSCs differentiation into neurons. The P/G-Met-CD80 mAb scaffolds with specific immunomodulatory functions and neurogenic potential provide a new strategy for repairing SCI in the clinic.
Source: openalex_inverted_index · Quality: baseline

Research context

PolymersBiomaterials

OpenAlex topics: Nerve injury and regeneration · RNA Interference and Gene Delivery · Spinal Cord Injury Research

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Orthopedics, The First Affiliated Hospital of Soochow University, Medical College of Soochow University, Orthopedic Institute of Soochow University, 899 Pinghai Road, Suzhou, Jiangsu 215031, People’s Republic of China

Department of Orthopedics, The Second Affiliated Hospital of Soochow University, 1055 Sanxiang Road, Suzhou, Jiangsu 215004, People’s Republic of China

Department of Orthopedics, The Affiliated Huai’an No. 1 People’s Hospital of Nanjing Medical University, 1 Huanghe West Road, Huaian, Jiangsu 223300, People’s Republic of China

Chinese Academy of Sciences Key Laboratory of Nano-Bio Interface, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, 398 Ruoshui Road, Suzhou, Jiangsu 215123, People’s Republic of China

Funding

China Postdoctoral Science Foundation · National Natural Science Foundation of China · Jiangsu Funding Program for Excellent Postdoctoral · Key Laboratory of Orthopaedics of Suzhou · Postgraduate Research & Practice Innovation Program of Jiangsu Province · Natural Science Research project of Huai?an · Technology Innovation on Medicine and Health of Suzhou Science and Technology Bureau

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