DataVXACS Materials LettersPaper
journal article·2024-08-05Open access

The Dimensionality of Hydrogen Bond Networks Induces Diverse Physical Properties of Peptide Crystals

Hui Yuan, Pierre-Andre Cazade, Chengqian Yuan, Bin Xue, Vijay Bhooshan Kumar, Rusen Yang, Gal Finkelstein-Zuta, Lihi Gershon, Maoz Lahav, Sigal Rencus-Lazar, Yi Cao, Davide Levy, Damien Thompson, Ehud Gazit

ACS Materials Letters· Volume 6· Issue 8
Publisher pageOpen full text
Source abstract

Abstract

Short peptides are attractive building blocks for the fabrication of self-assembled materials with significant biological, chemical, and physical properties. The microscopic and macroscopic properties of assemblies are usually closely related to the dimensionality of formed hydrogen bond networks. Here, two completely different supramolecular architectures connected by distinct hydrogen bond networks were obtained by simply adding a hydroxyl group to switch from cyclo-tryptophan-alanine (cyclo-WA) to cyclo-tryptophan-serine (cyclo-WS). While hydroxyl-bearing cyclo-WS molecules provided an additional hydrogen bond donor that links to adjacent molecules, forming a rigid three-dimensional network, cyclo-WA arranged into a water-mediated zipper-like structure with a softer two-dimensional layer template. This subtle alteration resulted in a 14-fold enhancement of Young's modulus values in cyclo-WS compared to cyclo-WA. Both cyclo-dipeptides exhibit biocompatibility, high fluorescence, and piezoelectricity. The demonstrated role of dimensionality of hydrogen bond networks opens new avenues for rational design of materials with precise morphologies and customizable properties for bioelectronic applications.
Source: openalex_inverted_index · Quality: baseline

Research context

Biomaterials

OpenAlex topics: Supramolecular Self-Assembly in Materials · Chemical Synthesis and Analysis · Antimicrobial Peptides and Activities

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

The Shmunis School of Biomedicine and Cancer Research, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 6997801, Israel

Department of Physics, Bernal Institute, University of Limerick, Limerick V94 T9PX, Ireland

State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China

National Laboratory of State Microstructure, Department of Physics, Nanjing University, Nanjing 210093, Jiangsu, China

Academy of Advanced Interdisciplinary Research, School of Advanced Materials and Nanotechnology, Xidian University, Xi’an 710126, China

Center for Nanoscience and Nanotechnology, Wolfson Applied Materials Research Center, University of Tel Aviv, Tel Aviv 6997801, Israel

Funding

State Key Laboratory of Fluid Power and Mechatronic Systems · Ministry of Science and Technology of the People's Republic of China · HORIZON EUROPE Widening participation and spreading excellence · Science Foundation Ireland · Ministry of Science, Technology and Space · Chinese Academy of Sciences · ISF- Israel Science Foundation

References (52)

Show source-provided references
1. 10.1039/b605536m10.1039/b605536m ↗
2. 10.1016/S1369-7021(10)70013-410.1016/S1369-7021(10)70013-4 ↗
3. 10.1080/1061027041233132894310.1080/10610270412331328943 ↗
4. 10.1039/C4CS00247D10.1039/C4CS00247D ↗
5. 10.1038/s41557-020-0452-110.1038/s41557-020-0452-1 ↗
6. 10.1039/b921448h10.1039/b921448h ↗
7. 10.1038/s41570-019-0129-810.1038/s41570-019-0129-8 ↗
8. 10.1021/acs.accounts.3c0059210.1021/acs.accounts.3c00592 ↗
9. 10.1038/nnano.2015.2710.1038/nnano.2015.27 ↗
10. 10.1038/3501504310.1038/35015043 ↗
11. 10.1002/anie.20100344610.1002/anie.201003446 ↗
12. 10.1038/s41563-019-0343-210.1038/s41563-019-0343-2 ↗
13. 10.1038/ncomms1356610.1038/ncomms13566 ↗
14. 10.1039/C5CS00941C10.1039/C5CS00941C ↗
15. 10.34133/2019/902593910.34133/2019/9025939 ↗
16. 10.1038/nnano.2008.31410.1038/nnano.2008.314 ↗
17. 10.1126/science.abf215510.1126/science.abf2155 ↗
18. 10.1039/C4CS00164H10.1039/C4CS00164H ↗
19. 10.1002/adfm.20170432810.1002/adfm.201704328 ↗
20. 10.1002/adma.20170455110.1002/adma.201704551 ↗
21. 10.1021/acs.iecr.0c0291010.1021/acs.iecr.0c02910 ↗
22. 10.1021/acs.accounts.8b0013110.1021/acs.accounts.8b00131 ↗
23. 10.1002/anie.20221418410.1002/anie.202214184 ↗
24. 10.1002/adfm.20210252410.1002/adfm.202102524 ↗
25. 10.1016/j.ccr.2008.01.00510.1016/j.ccr.2008.01.005 ↗
26. 10.1002/psc.282910.1002/psc.2829 ↗
27. 10.1007/s10853-015-8875-610.1007/s10853-015-8875-6 ↗
28. 10.1039/C5SM00533G10.1039/C5SM00533G ↗
29. 10.1021/acs.chemmater.8b0320610.1021/acs.chemmater.8b03206 ↗
30. 10.1021/acsami.2c1339910.1021/acsami.2c13399 ↗
31. 10.1038/s43586-021-00065-810.1038/s43586-021-00065-8 ↗
32. 10.1039/C7CS00817A10.1039/C7CS00817A ↗
33. 10.1063/1.514175710.1063/1.5141757 ↗
34. 10.1016/j.carbpol.2009.08.04010.1016/j.carbpol.2009.08.040 ↗
35. 10.1038/sj.leu.240301910.1038/sj.leu.2403019 ↗
36. 10.1002/jrs.142410.1002/jrs.1424 ↗
37. 10.2138/am.2006.217910.2138/am.2006.2179 ↗
38. 10.1016/j.saa.2006.02.04510.1016/j.saa.2006.02.045 ↗
39. 10.1002/anie.20110394110.1002/anie.201103941 ↗
40. 10.1107/S160057672100291010.1107/S1600576721002910 ↗
41. 10.1039/B818330A10.1039/B818330A ↗
42. 10.1021/cg060773k10.1021/cg060773k ↗
43. 10.1002/anie.20150581310.1002/anie.201505813 ↗
44. 10.34133/research.004610.34133/research.0046 ↗
45. 10.1208/s12249-009-9187-410.1208/s12249-009-9187-4 ↗
46. 10.1016/j.nanoen.2023.10837510.1016/j.nanoen.2023.108375 ↗
47. 10.1002/adma.20110173310.1002/adma.201101733 ↗
48. 10.1021/acsabm.8b0064710.1021/acsabm.8b00647 ↗
49. 10.1039/c3cp43952f10.1039/c3cp43952f ↗
50. 10.1038/s41524-020-00360-010.1038/s41524-020-00360-0 ↗
51. 10.1021/jacs.5b1101210.1021/jacs.5b11012 ↗
52. 10.1038/nnano.2015.2710.1038/nnano.2015.27 ↗