journal article·2022-09-05

A Photoactivatable AIEgen for Selective Imaging and Killing of Estrogen Receptor-Positive Cells

Changhuo Xu, Hang Zou, Lianrui Hu, Hanchen Shen, Herman H. Y. Sung, Haitao Feng, Ryan T. K. Kwok, Jacky W. Y. Lam, Lei Zheng, Ben Zhong Tang

ACS Materials Letters· Volume 4· Issue 9
Publisher page

Abstract

The development of fluorescent probes based on the skeletal structure of small-molecule targeted anticancer drugs is promising for biomedical applications because these probes generally show trackable fluorescence and connatural bioactivity inherited from the parental anticancer drugs. By mimicking a classic estrogen receptor (ER) antagonist, namely, tamoxifen, we herein design and synthesize a photoactivatable luminogen with aggregation-induced emission and medicinal benefits. The probe is weakly emissive when it is selectively internalized by estrogen receptor-positive cells. Under photoirradiation, its emission can be turned on to report the intracellular distribution. The cell viability assay suggests that the probe only exhibits cytotoxicity to ER-positive cells but negligible cytotoxicity to ER-negative cells. This study thus provides new access to targeted theranostic systems with photoactivity.
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Research context

OpenAlex topics: Nanoplatforms for cancer theranostics · Luminescence and Fluorescent Materials · Click Chemistry and Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Chemistry, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, Division of Life Science, State Key Laboratory of Molecular Neuroscience, Guangdong-Hong Kong-Macau Joint Laboratory of Optoelectronic and Magnetic Functional Materials, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, 999077 Hong Kong, China

Department of Laboratory Medicine, Nanfang Hospital, Southern Medical University, 510515 Guangzhou, China

AIE Research Center, Shaanxi Key Laboratory of Phytochemistry, College of Chemistry and Chemical Engineering, Baoji University of Arts and Sciences, 721013 Baoji, China

School of Science and Engineering, Shenzhen Institute of Aggregate Science and Technology, The Chinese University of Hong Kong, Shenzhen, Guangdong 518172, China

Funding

Research Grants Council, University Grants Committee · Innovation and Technology Commission · National Natural Science Foundation of China · Natural Science Foundation of Guangdong Province · Science and Technology Innovation as a Whole Plan Projects of Shaanxi Province

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