journal article·2024-09-02

Cavity-Size-Adjustable Macrocycles as a Novel Vaccine Adjuvant for Tumor Immunotherapy

Yuna Shang, Fan Zhang, Zhongyan Wang, Hongjing Luo, Hui Liu, Jiayi Lu, Yinyin Feng, Jiayu Wang, Aifeng Liu, Chao Zhang, Bin Li, Junyi Chen, Ming Dong, Chunju Li

ACS Materials Letters· Volume 6· Issue 9
Publisher page

Abstract

In this study, we constructed a macrocycle-based vaccine system driving antigen accumulation in lymph nodes. The capabilities of antigen delivery and immune activation as vaccine adjuvants are based on three positively charged water-soluble biphen[3]arenes (WP 3s: WTP3, WQP3, and WPP3) with different cavity sizes were synchronously investigated. Compared to the OVA group, WTP3, WQP3, and WPP3 exhibited a significant increase in the IgG antibody titer by ∼ 2.3 × 10 2 -, 2.7 × 10 3 -, and 7.6 × 10 3 -fold, respectively. Therefore, we are convinced that biphen[3]arenes with larger cavity sizes not only demonstrate enhanced protein loading and binding capacity in vitro, but also manifest prolonged antigen retention time and heightened immune activation ability in vivo. To the best of our knowledge, this study represents the initial exploration of the impact of macrocyclic cavity sizes on the efficiency of antigen delivery as well as its potential influence on immune response capabilities.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: RNA Interference and Gene Delivery · Supramolecular Chemistry and Complexes · Supramolecular Self-Assembly in Materials

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Academy of Interdisciplinary Studies on Intelligent Molecules, Tianjin Key Laboratory of Structure and Performance for Functional Molecules, College of Chemistry, Tianjin Normal University, Tianjin 300387, People’s Republic of China

Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300192, People’s Republic of China

Henan Key Laboratory of Immunology and Targeted Drug, Henan Collaborative Innovation Center of Molecular Diagnosis and Laboratory Medicine, School of Laboratory Medicine, Xinxiang Medical University, Xinxiang, Henan 453003, People’s Republic of China

National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, People’s Republic of China

Funding

Science and Technology Department of Henan Province · National Natural Science Foundation of China

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