DataVXACS Materials LettersPaper
journal article·2024-08-05

Photoimmunotherapy-Induced Pyroptosis Remodels the Microenvironment to Enhance Cancer Immunotherapy

Wenqiao Zhang, Haitao Yuan, Peili Wang, Letai Yi, Qinglian Wen, Runhua Zhou, Yunmeng Bai, Jingbo Ma, Xiaoxian Wang, Yanting Liang, Zhen Liang, Xin Peng, Jigang Wang, Wei Xiao

ACS Materials Letters· Volume 6· Issue 8
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Source abstract

Abstract

Immunosuppressive tumor microenvironment (TME) and immune escape are the main reasons that make immunotherapy ineffective and even hinder tumor progression. Immunogenic cell death (ICD) based on pyroptosis stands up as an ideal strategy to overcome the TME and achieve satisfactory antitumor effects. In addition, the insight into activation of the cGAS-STING pathway afford an efficient means to enhance the antitumor immune effect. Hence, we report a tumor treatment strategy based on photosensitizer PDI-mediated photoimmunotherapy that enhances immunogenic pyroptosis by synergistically activating the cGAS-STING pathway of macrophages. In vitro and in vivo studies showed that this light-activated immunotherapy could stimulate a strong antitumor immune response and achieve good antitumor efficacy in combination with immune checkpoint inhibitors. Our work sheds light on developing photoimmunotherapy to improve the immunosuppressive tumor microenvironment and simultaneously promote immune-mediated tumor regression.
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Research context

OpenAlex topics: Inflammasome and immune disorders · Heme Oxygenase-1 and Carbon Monoxide · Travel-related health issues

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

State Key Laboratory of Antiviral Drugs, School of Pharmacy, Henan University, Kaifeng, 475004, China

Department of Critical Medicine, Shenzhen Clinical Research Centre for Geriatrics, Shenzhen People’s Hospital, The First Affiliated Hospital, Southern University of Science and Technology, Shenzhen 518020, Guangdong China

Department of Oncology, The Affiliated Hospital of Southwest Medical University, Southwest Medical University, Luzhou 646000, Sichuan China

Key Laboratory of Glucolipid Metabolic Disorder, Ministry of Education, Guangdong Pharmaceutical University, Guangzhou, Guangdong 510006, China

National Clinical Research Center for Chinese Medicine Cardiology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100000, China

Inner Mongolia Medical University, Hohhot 010000, Inner Mongolia China

Department of Traditional Chinese Medicine and School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China

Ningbo Municipal Hospital of TCM, Affiliated Hospital of Zhejiang Chinese Medical University, Ningbo 315000, Zhejiang China

State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, Artemisinin Research Center, and Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, P.R. China

Funding

National Key Research and Development Program of China · Science and Technology Foundation of Shenzhen City · Basic and Applied Basic Research Foundation of Guangdong Province · China Postdoctoral Science Foundation · Science, Technology and Innovation Commission of Shenzhen Municipality · State Administration of Traditional Chinese Medicine of the People's Republic of China · Shenzhen Medical Research Fund · Shenzhen Governmental Sustainable Development Fund · Shenzhen Fund for Guangdong Provincial High-level Clinical Key Specialties · Distinguished Expert Project of Sichuan Province Tianfu Scholar · International Science and Technology Cooperation for Shenzhen Technology Innovation Plan

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