DataVXACS Materials LettersPaper
journal article·2024-02-05

Poly(alkylideneamine) Dendrimer Nanogels Codeliver Drug and Nucleotide To Alleviate Anticancer Drug Resistance through Immunomodulation

Yue Gao, Zhijun Ouyang, Gaoming Li, Qiuyu Yu, Waicong Dai, João Rodrigues, Andrij Pich, Meera Moydeen Abdul Hameed, Mingwu Shen, Xiangyang Shi

ACS Materials Letters· Volume 6· Issue 2
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Source abstract

Abstract

The development of drug delivery strategies with the desired immunomodulation effects to alleviate tumor drug resistance remains a challenge. Herein, low-generation poly(alkylideneamine) dendrimer nanogels (DNGs) were developed to codeliver chemotherapeutics 5-fluorouracil (5-FU) and immune agonist cyclic GMP-AMP (cGAMP) for tumor chemoimmunotherapy. The DNGs possess a hydrodynamic size of 145.6 nm, excellent drug/nucleotide coloading capacity, and pH-sensitive drug release profile. The 5-FU-loaded DNGs can overcome 5-FU resistance through prolonged cellular retention and downregulation of P-glycoprotein expression on the cancer cell surface. Meanwhile, the cGAMP in the codelivery system can activate the stimulator of interferon genes pathway in cancer cells, which further relives drug resistance and modulates tumor microenvironment through maturation of dendritic cells and macrophage M1 polarization. The immunomodulation-facilitated drug resistance alleviation was confirmed in vivo in a subcutaneous colorectal tumor mouse model, leading to relatively long tumor drug retention, inhibition of tumor growth, and generation of active antitumor immune responses.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Dendrimers and Hyperbranched Polymers · RNA Interference and Gene Delivery · Immunotherapy and Immune Responses

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, College of Biological Science and Medical Engineering, Donghua University, Shanghai 201620, China

CQM - Centro de Química da Madeira, Universidade da Madeira, Campus Universitário da Penteada, 9020-105 Funchal, Portugal

DWI-Leibniz-Institute for Interactive Materials, 52074 Aachen, Germany

Institute for Technical and Macromolecular Chemistry, RWTH Aachen University, 52074 Aachen, Germany

Aachen Maastricht Institute for Biobased Materials, Maastricht University, 6167 RD Geleen, The Netherlands

Department of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia

Funding

National Key Research and Development Program of China · King Saud University · Science and Technology Commission of Shanghai Municipality · China Scholarship Council · Fundamental Research Funds for the Central Universities · National Natural Science Foundation of China

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