DataVXACS Materials LettersPaper
journal article·2024-02-05

Bioorthogonal Activation of RCA-Based Amplifiable DNAzymes in Bimetallic NMOF for Precise Gene/Chemo-Dynamic Combination Therapy

Ting Huang, Wei-Lun Pan, Ming-Shun Li, Yi-Ming Zou, Wei Meng, Min-Min Li, Wen-Hua Zhang, Zong Dai, Jin-Xiang Chen, Jun Chen

ACS Materials Letters· Volume 6· Issue 2
Publisher page
Source abstract

Abstract

Controllable and sufficient concentrations of therapeutic agents in gene therapy are critical to achieve satisfactory outcomes. Herein, a Zn 2+ /Cu 2+ bimetallic nano metal–organic framework loaded with rolling circle amplification (RCA) substrates (termed PZCT) was established for precise and efficient DNAzyme-based gene and chemo-dynamic combined therapy. The activation of PZCT is bioorthogonally controlled by tumor-specific miR-21, which generates numerous DNAzyme for silencing EGR-1 mRNA with the assistance of Zn 2+ from PZCT. Simultaneously, the doped copper ions on PZCT exert chemo-dynamic therapy (CDT) by reducing glutathione (GSH) and converting endogenous hydrogen peroxide (H 2 O 2 ) into hydroxyl radical (·OH). These combination therapies exhibited remarkable tumor elimination effects in vivo and promised excellent tumor specificity via a bioorthogonal strategy. The proposed nanoplatform offers new prospects for precise cancer therapeutics by overcoming low transfection efficiency and off-target toxicity in DNAzyme-based approaches.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Advanced biosensing and bioanalysis techniques · RNA Interference and Gene Delivery · Nanoplatforms for cancer theranostics

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

NMPA Key Laboratory for Research and Evaluation of Drug Metabolism, Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China

Center of Clinical Laboratory, The First Affiliated Hospital of Jinan University, Guangzhou 510632, China

College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China

School of Biomedical Engineering, Sun Yat-Sen University, Guangzhou 510275, China

Key Laboratory of Optic-electric Sensing and Analytical Chemistry for Life Science, MOE, Qingdao University of Science and Technology, Qingdao 266510, China

Funding

Ministry of Education of the People's Republic of China · Basic and Applied Basic Research Foundation of Guangdong Province · Guangzhou Municipal Science and Technology Bureau · Jinan University · National Natural Science Foundation of China

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