journal article·2024-10-07

π-Bridge Regulates Donor–Acceptor Interactions for Long-Wavelength Photoacoustic Imaging and Enhanced Photothermal Therapy

Ying Gu, Hanjian Lai, Shijie Ruan, Yulin Zhu, Pengbo Ding, Guiling Fan, Lei Xi, Liang Guo, Feng He, Leilei Tian

ACS Materials Letters· Volume 6· Issue 10
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Abstract

Acceptor–donor–acceptor (A-D-A) structured π-conjugated molecules emerge as a new class of phototheranostic materials. The π-bridge has rarely been investigated for structure engineering compared with the D and A units. This work reveals that changing ethylene into a butadiene π-bridge can efficiently extend absorption wavelength and promote the nonradiative transition. Specifically, the butadiene π-bridge not only extends the π-conjugation length but also disrupts the S···O interlocking, which facilitates intramolecular torsions and rotations and enhances the intramolecular charge transfer for the molecule with butadiene π-bridge. As a result, very broad absorption with a 70 nm red-shift is observed, and the power conversion efficiency (PCE) of BTVIC nanoparticles reaches 82.6%. Ultimately, photoacoustic imaging (PAI)-guided photothermal therapy (PTT) applications in vivo demonstrate a deep penetration depth of over 7 mm and an efficient anti-tumor effect. This work illustrates that modifying the π-bridge is a practical strategy for regulating A-D-A interactions and developing more efficient phototheranostic agents.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Nanoplatforms for cancer theranostics · Photoacoustic and Ultrasonic Imaging · Luminescence and Fluorescent Materials

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Materials Science and Engineering, Southern University of Science and Technology, 1088 Xueyuan Blvd., Nanshan District, Shenzhen, Guangdong 518055, P. R. China

Department of Chemistry, Shenzhen Grubbs Institute and Guangdong Provincial Key Laboratory of Catalysis, Southern University of Science and Technology, 1088 Xueyuan Blvd., Nanshan District, Shenzhen, Guangdong 518055, P. R. China

Department of Biomedical Engineering, Southern University of Science and Technology, 1088 Xueyuan Blvd., Nanshan District, Shenzhen, Guangdong 518055, P. R. China

Department of Mechanical and Energy Engineering, Southern University of Science and Technology, 1088 Xueyuan Blvd., Nanshan District, Shenzhen, Guangdong 518055, P. R. China

Department of Chemistry, The Hong Kong University of Science and Technology, Hong Kong 999077, China

Department of Mechanical and Energy Engineering, SUSTech Energy Institute for Carbon Neutrality, Southern University of Science and Technology, 1088 Xueyuan Blvd., Nanshan District, Shenzhen, Guangdong 518055, P. R. China

Funding

Guangdong Provincial Key Laboratory Of Catalysis · Shenzhen Municipal Fundamental Research Program · Basic and Applied Basic Research Foundation of Guangdong Province · Southern University of Science and Technology · National Natural Science Foundation of China · Shenzhen Sci-Tech Fund

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