Novel NIR-II 3,5-Julolidinyl aza-BODIPY for Photothermal Therapy of Gliomas Stem Cells by Brain Stereotactic Injection
Source abstract
Abstract
Functional dyes with absorption in the second near-infrared window (NIR-II) show great promise in photothermal therapy. Herein, the novel NIR-II 3,5-julolidinyl aza-BODIPY ( JLD ) was prepared and confirmed by X-ray crystallographic analysis for the first time. The molecular packing structure facilitates the J -aggregation packing mode. Self-assembled JLD -nanoparticles ( JLD -NPs) emit fluorescence (λ em = 962 nm, Φ f = 0.1%), and a peak belt covered a NIR-II range of 900–1300 nm. The photothermal conversion efficiency was high and was calculated to be 79%. JLD -NPs with NIR-II 915 nm laser irradiation had the good tumor-inhibition capability with promoting the apoptosis and inhibiting the stemness of glioblastoma cells by brain stereotactic injection and affect the occurrence of malignant events, such as migration and invasion.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Nanoplatforms for cancer theranostics · Luminescence and Fluorescent Materials · Advanced Nanomaterials in Catalysis
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Liaoning & Shenyang Key Laboratory of Functional Dye and Pigment, Shenyang University of Chemical Technology, Shenyang 110142, China
Department of Neurology, the Fourth Affiliated Hospital of China Medical University, Shenyang 110032, China
Science Experiment Center, China Medical University, Shenyang 110032, China
State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116024, China
Department of Chemistry, Graduate School of Advanced Science and Engineering, Hiroshima University, Higashi-Hiroshima 7398526, Japan
Funding
Shenyang University of Chemical Technology · China Medical University · National Natural Science Foundation of China
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