journal article·2024-05-06

Synergistically Enhanced Chemodynamic Therapy Induced by NIR-II Photothermal Therapy with MRI/CT Imaging Guidance for Colorectal Cancer

Zhusheng Liu, Chengyuan Hong, Chunshu Pan, Yanzi Sun, Yagui Lv, Yuanyuan Wei, Xinfangzi Wang, Wen Zang, Quanliang Mao, Xiaoxia Deng, Pengyu Wang, Weihao Zhu, Tianxiang Chen, Manxiang Wu, Juan Li, Aiguo Wu

ACS Materials Letters· Volume 6· Issue 5
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Abstract

Chemodynamic therapy (CDT) exhibits unsatisfactory therapeutic efficacy for colorectal cancer (CRC) due to the hyposensitive Fenton reaction. Herein, we constructed a novel multifunctional nanoplatform based on bismuth-doped iron selenide nanoparticles (BFS NPs) for promoting the therapeutic performance of CDT on CRC. BFS NPs can realize CDT and second near-infrared photothermal therapy (NIR-II PTT) by means of the Fenton reaction and an excellent photothermal conversion efficiency (η = 31.9%). Moreover, the rising temperature induced by NIR irradiation accelerates the Fenton reaction rate because of there being more activated H 2 O 2, thereby improving reactive oxygen species (ROS) levels to address the insufficient hydrogen peroxide concentration. The results showed that the combination of CDT with NIR-II PTT significantly inhibits the growth of CRC and minimizes adverse reactions. Meanwhile, bismuth doping endows the BFS NPs with superior CT imaging and T 2 -weighted magnetic resonance imaging (T 2 -MRI) capacities. These unique properties offer an appropriate treatment time window for guiding NIR-II PTT. In summary, this nanoplatform improves the therapeutic effect of CDT and accurately regulates NIR-II PTT by MRI/CT imaging guidance, which provides a new perspective for effective and precise therapy of CRC.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Nanoplatforms for cancer theranostics · Advanced Nanomaterials in Catalysis · Photoacoustic and Ultrasonic Imaging

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Ningbo Key Laboratory of Biomedical Imaging Probe Materials and Technology, Zhejiang International Cooperation Base of Biomedical Materials Technology and Application, Chinese Academy of Sciences (CAS) Key Laboratory of Magnetic Materials and Devices, Ningbo Cixi Institute of Biomedical Engineering, Zhejiang Engineering Research Center for Biomedical Materials, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo 315201, P.R. China

Cixi Biomedical Research Institute, Wenzhou Medical University, Zhejiang 315300, P.R. China

Department of Mechanical, Materials and Manufacturing Engineering, University of Nottingham Ningbo China, 199 Taikang East Road, Ningbo 315100, P.R. China

Department of Radiology, Ningbo NO.2 Hospital, Ningbo 315042, P.R. China

Ningbo Clinical Research Center for Medical Imaging, Ningbo 315010, P.R. China

Department of Radiology, The Affiliated People’s Hospital of Ningbo University, Ningbo 315040, P.R. China

Funding

Natural Science Foundation of Ningbo Municipality · Medical Science and Technology Project of Zhejiang Province · National Natural Science Foundation of China · Chinese Academy of Sciences · Ningbo Clinical Research Center for Medical Imaging · Provincial and Municipal Co-construction Key Discipline for Medical Imaging

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