DataVXACS Materials LettersPaper
journal article·2023-06-05

Chromium Nanoparticles Improve Macrophage and T Cell Infiltration for Cancer Immunotherapy

Quan Liu, Zhe Sun, Yanhong Duo, Lei Yin, Kongpeng Lv, Ludan Yue, Qian-Fang Meng, Dingmeng Nie, Jiaojuan Chen, Dixian Luo, Li-Ping Liu, Lang Rao

ACS Materials Letters· Volume 5· Issue 6
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Source abstract

Abstract

Immune checkpoint blockade has been regarded as a highly promising cancer immunotherapy approach. However, inefficient immune cell infiltration and the immunosuppressive tumor microenvironment (TME) remain significant causes of low clinical response rates. Here, we identified that trivalent chromium irons (Cr 3+ ) could enhance tumor infiltration of immune cells including M1-type tumor-associated macrophages and CD8 + T cells. Mechanistically, this effect is dependent on the expression of macrophage inflammatory protein-1α (MIP-1α) and the PI3K/Akt/mTOR pathway. Moreover, the Cr-based nanoparticles (Cr NPs) exhibited superior photothermal properties under near-infrared laser irradiation, showing great potential in transforming “cold” tumors into “hot” ones. In combination with the PD-1/PD-L1 pathway inhibitor, we demonstrated that the Cr NPs significantly improved anticancer efficacy in mouse models of hepatoma and melanoma by increasing antitumor immune cell infiltration and relieving immunosuppressive TME. Overall, the Cr NPs offer a new dual-functional platform for local and systemic cancer treatments, paving the way toward cancer photometalloimmunotherapy.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Nanoplatforms for cancer theranostics · Cancer Immunotherapy and Biomarkers · Immune cells in cancer

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Division of Hepatobiliary and Pancreas Surgery, Department of General Surgery, Shenzhen People’s Hospital, (The Second Clinical Medical College, Jinan University, and The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen 518020, People’s Republic of China

Department of Laboratory Medicine, Huazhong University of Science and Technology Union Shenzhen Hospital (Nanshan Hospital), Shenzhen University, Shenzhen 518052, People’s Republic of China

Institute of Biomedical Health Technology and Engineering, Shenzhen Bay Laboratory, Shenzhen 518132, People’s Republic of China

Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, Stockholm 17177, Sweden

Department of Interventional Radiology, Shenzhen People’s Hospital, (The Second Clinical Medical College, Jinan University, and The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen 518020, People’s Republic of China

Funding

Shenzhen Bay Laboratory · Basic and Applied Basic Research Foundation of Guangdong Province · National Natural Science Foundation of China · Science and Technology Innovation Commission of Shenzhen

References (52)

Show source-provided references
1. 10.1038/nrd.2015.3510.1038/nrd.2015.35 ↗
2. 10.1038/nrc323910.1038/nrc3239 ↗
3. 10.1038/s41577-019-0218-410.1038/s41577-019-0218-4 ↗
4. 10.1038/s41568-021-00339-z10.1038/s41568-021-00339-z ↗
5. 10.1038/s41568-019-0183-z10.1038/s41568-019-0183-z ↗
6. 10.1016/j.immuni.2018.03.00710.1016/j.immuni.2018.03.007 ↗
7. 10.1038/s41577-021-00574-310.1038/s41577-021-00574-3 ↗
8. 10.1126/science.112913910.1126/science.1129139 ↗
9. 10.1038/nm.393110.1038/nm.3931 ↗
10. 10.1158/1078-0432.CCR-19-186810.1158/1078-0432.CCR-19-1868 ↗
11. 10.1038/s41573-018-0007-y10.1038/s41573-018-0007-y ↗
12. 10.1038/s41568-020-0283-910.1038/s41568-020-0283-9 ↗
13. 10.1038/s41571-020-0410-210.1038/s41571-020-0410-2 ↗
14. 10.1016/j.micinf.2011.10.00110.1016/j.micinf.2011.10.001 ↗
15. 10.1002/chem.20210443010.1002/chem.202104430 ↗
16. 10.1016/j.immuni.2013.05.01610.1016/j.immuni.2013.05.016 ↗
17. 10.1038/ncomms233910.1038/ncomms2339 ↗
18. 10.7554/eLife.4924810.7554/eLife.49248 ↗
19. 10.1126/science.aau648110.1126/science.aau6481 ↗
20. 10.1038/nrmicro283610.1038/nrmicro2836 ↗
21. 10.1038/s41565-021-00962-910.1038/s41565-021-00962-9 ↗
22. 10.1016/j.cell.2021.12.03910.1016/j.cell.2021.12.039 ↗
23. 10.1038/nature1169910.1038/nature11699 ↗
24. 10.1126/science.aau013510.1126/science.aau0135 ↗
25. 10.1126/science.aat102210.1126/science.aat1022 ↗
26. 10.1038/natrevmats.2017.2410.1038/natrevmats.2017.24 ↗
27. 10.1038/s41571-019-0308-z10.1038/s41571-019-0308-z ↗
28. 10.1126/scitranslmed.abb698110.1126/scitranslmed.abb6981 ↗
29. 10.1126/sciadv.abd163110.1126/sciadv.abd1631 ↗
30. 10.1111/j.1574-695X.2002.tb00596.x10.1111/j.1574-695X.2002.tb00596.x ↗
31. 10.1126/scitranslmed.abc281610.1126/scitranslmed.abc2816 ↗
32. 10.1038/s41565-018-0271-310.1038/s41565-018-0271-3 ↗
33. 10.1038/s41551-021-00826-610.1038/s41551-021-00826-6 ↗
34. 10.1038/s41565-022-01098-010.1038/s41565-022-01098-0 ↗
35. 10.1126/scitranslmed.aan368210.1126/scitranslmed.aan3682 ↗
36. 10.1002/adma.20190756810.1002/adma.201907568 ↗
37. 10.1021/acs.chemrev.9b0044510.1021/acs.chemrev.9b00445 ↗
38. 10.1002/adma.20170085010.1002/adma.201700850 ↗
39. 10.1021/acsnano.7b0423010.1021/acsnano.7b04230 ↗
40. 10.1021/acs.chemrev.8b0039610.1021/acs.chemrev.8b00396 ↗
41. 10.1073/pnas.201435211710.1073/pnas.2014352117 ↗
42. 10.1038/s41551-021-00807-910.1038/s41551-021-00807-9 ↗
43. 10.1039/D1CS00609F10.1039/D1CS00609F ↗
44. 10.1002/adfm.20200439710.1002/adfm.202004397 ↗
45. 10.1038/s41467-021-23194-w10.1038/s41467-021-23194-w ↗
46. 10.1371/journal.pone.022833910.1371/journal.pone.0228339 ↗
47. 10.1038/s41467-020-18626-y10.1038/s41467-020-18626-y ↗
48. 10.1039/C5MB00101C10.1039/C5MB00101C ↗
49. 10.1021/acs.chemrev.7b0025810.1021/acs.chemrev.7b00258 ↗
50. 10.1038/s41551-020-0599-510.1038/s41551-020-0599-5 ↗
51. 10.1016/j.tiv.2006.10.00210.1016/j.tiv.2006.10.002 ↗
52. 10.1038/s41551-022-00978-z10.1038/s41551-022-00978-z ↗