Neuraminidase-Activatable NIR Fluorescent Probe for Influenza Virus Ratiometric Imaging in Living Cells and Colorimetric Detection on Cotton Swabs
Source abstract
Abstract
Influenza, as one of the most serious communicable respiratory infectious diseases, is caused by influenza viruses. Neuraminidase (NA), also referred to as sialidase, is an important protein on the influenza virus surface. Because of its enzymatic function, NA has been selected as a promising target to develop influenza virus diagnosis reagents or drugs. Herein, a neuraminidase-responsive, light-up, near-infrared (NIR) fluorescence probe ( SA-DCM ) was reported that possesses both ratiometric and colormetric properties for different applications. Benefitting from the ratiometric properties, SA-DCM showed an increased anti-interference capacity for environmental fluctuation and enhanced detection accuracy with a large Stokes shift (>150 nm) and outstanding sensitivity and selectivity. Due to its colorimetric property, a color shift of the product HO-DCM from yellow to purple occurs when the pH value is adjusted. Therefore, a colorimetric approach through direct color conversion on a cotton swab to detect NA was established, and the result could be directly read by the naked eye with simplicity and practicality.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Nanoplatforms for cancer theranostics · Advanced biosensing and bioanalysis techniques · Click Chemistry and Applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Frontiers Science Center for Cell Responses, State Key Laboratory of Medicinal Chemical Biology Key Laboratory of Bioactive Materials, Ministry of Education, and College of Life Sciences, Nankai University, Tianjin 300071, China
College of Pharmacy and KLMDASR of Tianjin, Drug Discovery Center for Infectious Disease, Nankai University, No.38 Tongyan Road, Haihe Education Park, Tianjin 300350, China
College of Chemistry, Nankai University, Tianjin 300071, China
Department of Urology, Tianjin First Central Hospital, Tianjin 300384, China
Funding
Natural Science Foundation of Tianjin City · Ministry of Science and Technology of the People's Republic of China · National Natural Science Foundation of China · Tianjin Key Medical Discipline Construction Project · Tianjin Science Fund for Distinguished Young Scholars · Tianjin Health Science and technology project
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