journal article·2023-01-02

Enhancing NIR-II Phosphorescence through Phosphorescence Resonance Energy Transfer for Tumor-Hypoxia Imaging

Wansu Zhang, Shangyu Chen, Shuai Ye, Pengfei Sun, Quli Fan, Jun Song, Pengju Zeng, Jun-Le Qu, Wai-Yeung Wong

ACS Materials Letters· Volume 5· Issue 1
Publisher page

Abstract

Phosphorescence probes have emerged as a promising hypoxia detector for their excellent characters of long luminescence lifetime, large Stokes shift, and oxygen sensitivity. However, the low quantum yields of organic phosphorescence probes in the second near-infrared wavelength window (NIR-II, 1000–1700 nm) hinder their further development of NIR-II hypoxia imaging. Herein, this study reports a new NIR-II phosphorescence probe (PRET NPs) containing a phosphorescent long-lived triplet energy donor (PD) and a NIR-II fluorescent energy acceptor (FA) by using phosphorescence resonance energy transfer (PRET) strategy. Because of the suitable spectral overlap of PD and FA, PRET NPs exhibit high NIR-II quantum yield in both normoxic and oxygen-free atmospheres. Based on that, in the in vivo tumor hypoxia imaging experiments, PRET NPs also exhibit high brightness and signal-to-background ratio (SBR) of NIR-II tumor-hypoxia imaging. Therefore, this study illustrates a general approach based on “PRET” strategy to develop bright NIR-II phosphorescent probes.
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Research context

OpenAlex topics: Nanoplatforms for cancer theranostics · Luminescence and Fluorescent Materials · Analytical Chemistry and Sensors

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Applied Biology and Chemical Technology and Research Institute for Smart Energy, The Hong Kong Polytechnic University (PolyU), Hung Hom, Kowloon, Hong Kong, People’s Republic of China

PolyU Shenzhen Research Institute, Shenzhen518057, People’s Republic of China

Center for Biomedical Optics and Photonics (CBOP) & College of Physics and Optoelectronic Engineering, Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education/Guangdong Province, Shenzhen University, Shenzhen518060, People’s Republic of China

State Key Laboratory of Organic Electronics and Information Displays & Institute of Advanced Materials (IAM),Nanjing University of Posts Telecommunications, 9 Wenyuan Road, Nanjing210023, People’s Republic of China

National Research Nuclear University MEPhI (Moscow Engineering Physics Institute), 115409Moscow, Russian Federation

Funding

Research Grants Council, University Grants Committee · CAS-Croucher Funding Scheme for Joint Laboratories · Science, Technology and Innovation Commission of Shenzhen Municipality · National Natural Science Foundation of China · Hong Kong Polytechnic University · Guangdong-Hong Kong-Macao Joint Laboratory for Optoelectronic and Magnetic Functional Materials · Research Institute for Smart Energy, Hong Kong Polytechnic University

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