DataVXACS Materials LettersPaper
journal article·2023-04-03

Gelatin-Coated Copper-Based Metal–Organic Framework for Controlled Insulin Delivery: Possibility toward Oral Delivery System

Pawan Kumar, Navpreet Kaur, Pranav Tiwari, Anoop Kumar Gupta, Shaikh M. Mobin

ACS Materials Letters· Volume 5· Issue 4
Publisher page
Source abstract

Abstract

The development of nontoxic, hemocompatible materials for controlled insulin delivery is a great challenging task for researchers. Herein, we demonstrate the design of a novel linker 5,5′-((pyridine-2,6-diylbis(methylene)) bis(oxy))diisophthalic acid (H 4 L) and its utilization to synthesize a new Cu-MOF (IITI-3) . IITI-3 crystallizes in a tetragonal crystal system with space group I 4/ mmm and shows a high Brunauer–Emmett–Teller (BET) surface area of 1026.5 m 2 /g with pore diameter (Barrett–Joyner–Halenda pore size distribution) of 3.413 nm. The IITI-3 is found to be stable in the biological fluid pH ranges from 3 to 10. Moreover, IITI-3 were explored for insulin delivery by coating the IITI-3 with gelatin ( [email protected] ); the overall insulin was controlled from the framework. The obtained result paves a new avenue for the oral delivery of insulin using the IITI-3 metal-organic framework.
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Research context

OpenAlex topics: Metal-Organic Frameworks: Synthesis and Applications · Dendrimers and Hyperbranched Polymers · Nanoplatforms for cancer theranostics

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Chemistry, Indian Institute of Technology, Indore, Simrol, Khandwa Road, Indore 453552, India

Department of Biosciences and Bio-Medical Engineering, Indian Institute of Technology Indore, Simrol, Khandwa Road, Indore 453552, India

Department of Chemistry, Pandit Prithi Nath College (C. S. J. M. University), Mall Road, Kanpur 208001, Uttar Pradesh, India

Center for Electric Vehicle and Intelligent Transport Systems, Indian Institute of Technology Indore, Simrol, Khandwa Road, Indore 453552, India

Funding

University Grants Commission · Science and Engineering Research Board · Board of Research in Nuclear Sciences · Indian Institute of Technology Indore · Ministry of Education, India

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