DataVXACS Materials LettersPaper
journal article·2021-09-06

Targeted Photoacoustic Imaging of Brain Tumor Mediated by Neutrophils Engineered with Lipid-Based Molecular Probe

Xingang Liu, Yukun Duan, Dehong Hu, Min Wu, Chengjian Chen, Pramila Baban Ghode, Gayathiri Magarajah, Nitish Thakor, Xin Liu, Chengbo Liu, Zonghai Sheng, Hairong Zheng, Bin Liu

ACS Materials Letters· Volume 3· Issue 9
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Source abstract

Abstract

The delivery of imaging agents to brain tumor sites has been a longstanding hindrance, because of the presence of blood-brain barriers (BBB) and the complex brain tumor microenvironment. The living cell-based delivery system has shown tantalizing prospects for therapeutic applications targeting oncological diseases. Herein, we design a lipid-decorated molecular photoacoustic contrast agent TFML, which can effectively label harvested live neutrophils without affecting the activation and transmigration functions. After labeling neutrophils with TFML probes, TFML-labeled neutrophil (TFML-NE) was adoptively transferred into the recipient body and demonstrated strong PA signals, good brain tumor-targeting capability, and was applied for mice glioblastoma multiforme (GBM) detection. The successful development of TFML probes for neutrophil labeling and brain tumor targeting PAI presents a promising prospect for neutrophil-based nanotherapeutics studies.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Nanoplatforms for cancer theranostics · Photoacoustic and Ultrasonic Imaging · Extracellular vesicles in disease

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, 117585, Singapore

Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, People’s Republic of China

The N.1 Institute for Health, National University of Singapore, 28 Medical Drive #05-COR, Singapore 117456, Singapore

Joint School of National University of Singapore and Tianjin University, International Campus of Tianjin University, Binhai New City, Fuzhou 350207, China

Funding

National Research Foundation Singapore · National University of Singapore · National Natural Science Foundation of China · Chinese Academy of Sciences · Shenzhen Double Chain Grant · Science and Technology Key Project of Shenzhen · Shenzhen Key Laboratory of Ultrasound Imaging and Therapy

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