DataVXACS Materials LettersPaper
journal article·2022-01-03Open access

NIR-Light-Intensified Hypoxic Microenvironment for Cascaded Supra-Prodrug Activation and Synergistic Chemo/Photodynamic Cancer Therapy

Hongzhong Chen, Tao Sun, Weiwei Zeng, Xiaowei Zeng, Lin Mei, Chen Jiang, Yanli Zhao

ACS Materials Letters· Volume 4· Issue 1
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Source abstract

Abstract

Despite the fact that photodynamic therapy (PDT) has promising clinical prospects, its therapeutic efficacy is still restricted by the hypoxic tumor microenvironment (TME). Therefore, how to suitably employ tumor hypoxia is vital for optimizing PDT. Herein we developed a hypoxia-activated prodrug for combination therapy with PDT. A hypoxia-responsive camptothecin (CPT)-based prodrug and a near-infrared (NIR) BODIPY photosensitizer were coloaded within a β-cyclodextrin-based polymer through supramolecular host–guest recognition to obtain nanoparticles named CPT-BODIPY-PNs. After being internalized by the tumor, the oxygen in the tumor tissues was rapidly consumed by the photosensitizer moiety to generate reactive oxygen species under NIR irradiation. The prodrug was efficiently activated under this intensified hypoxic condition to release the chemotherapeutic CPT drug. This system makes the best use of hypoxia TME to achieve effectively combined PDT and chemotherapy, offering an approach for cancer treatment.
Source: openalex_inverted_index · Quality: baseline

Research context

PolymersNanomaterials

OpenAlex topics: Nanoplatforms for cancer theranostics · Cancer, Hypoxia, and Metabolism · Luminescence and Fluorescent Materials

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Institute of Pharmaceutics, School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Guangzhou 510275, China

Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, Singapore 637371, Singapore

Key Laboratory of Smart Drug Delivery, Ministry of Education, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai 201203, China

Tianjin Key Laboratory of Biomedical Materials, Key Laboratory of Biomaterials and Nanotechnology for Cancer Immunotherapy, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300192, China

Funding

Agency for Science, Technology and Research · Central University Basic Research Fund of China · National Research Foundation Singapore · National Natural Science Foundation of China

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