Optical Manipulation of CRISPR/Cas9 Functions: From Ultraviolet to Near-Infrared Light
Source abstract
Abstract
Optical manipulation has been widely exploited as a noninvasive and precise means for a wide range of biomedical applications, such as controlled drug release and neuron activation. Recent efforts that have been dedicated to the optical regulation of CRISPR/Cas9 systems greatly impart spatiotemporal specificity, fast reversibility, and remote controllability to genome editing and transcriptional modulation. Herein, we summarize the recent progresses of various optical strategies for manipulating CRISPR/Cas9 systems. In particular, emerging material strategies for the near-infrared optical control of CRISPR/Cas9 functions are also highlighted. Finally, current challenges and future outlooks in this field from material perspectives are discussed.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: CRISPR and Genetic Engineering · Advanced biosensing and bioanalysis techniques · RNA Interference and Gene Delivery
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China
Funding
Ministry of Education of the People's Republic of China · Ministry of Science and Technology of the People's Republic of China · National Natural Science Foundation of China · Leading Talent of "Ten Thousand Plan" - National High-Level Talents Special Support Plan
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