Highly Bright and Photostable Two-Dimensional Nanomaterials Assembled from Sequence-Defined Peptoids
Source abstract
Abstract
Free-standing two-dimensional (2D) organic nanomaterials are highly attractive for biological applications because of their unique structural properties and high biocompatibility. Herein, we designed and synthesized a new class of highly bright and photostable membrane-mimetic 2D nanosheets from sequence-defined peptoids. These nanosheets exhibited high quantum yield and photostability as a result of the precise placement and ordering of dansyl dye molecules within crystalline nanosheets. We further showed the use of these nanosheets as biocompatible and programmable probes for live cell imaging and cell labeling. By programing these nanosheets with different surface charges, we achieved the enhanced lysosome escape of these nanosheets, showing their great potential as nanocarriers for the efficient intracellular delivery of macromolecular drugs.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Luminescence and Fluorescent Materials · Advanced biosensing and bioanalysis techniques · Supramolecular Self-Assembly in Materials
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Physical Sciences Division, Pacific Northwest National Laboratory, Richland, Washington 99352, United States
School of Mechanical and Materials Engineering, Washington State University, Pullman, Washington 99164, United States
Department of Mechanical Engineering and Materials Science and Engineering Program, State University of New York, Binghamton, New York 13902, United States
College of Chemistry & Chemical Engineering, Linyi University, Linyi, Shandong 276005, China
Department of Chemical Engineering, University of Washington, Seattle, Washington 98195, United States
Funding
Basic Energy Sciences
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