Perspectives on the Next Generation of Sunscreen: Safe, Broadband, and Long-Term Photostability

Despite the burgeoning development and extensive commercialization of sunscreens, challenges remain regarding the biocompatibility and efficacy of commercial sunscreens. Direct exposure to UV filters has given rise to health problems, including the percutaneous penetration and the generation of reactive oxygen species. To address these, we have developed organic UV-filter self-framed microparticles, whereby organic UV-filter molecules self-construct into nanoparticles without any supportive microencapsulation. This approach is unique for its outstanding biocompatibility by reducing the percutaneous penetration of organic UV-filter molecules. Furthermore, the shielding range is extended from the UVB to the entire UV region by the introduction of a physical reflection effect. An in vitro fibroblast culture experiment and the results of in vivo skin protection experiments confirmed their safety. All the experimental results supported the conclusion that sunblock with self-framed microparticles (FSFMPs) has a great potential to become the next generation of UV filters for the UV protection of skin.