journal article·2022-04-04

NIR-II Absorbing Charge Transfer Complexes for Synergistic Photothermal–Chemodynamic Antimicrobial Therapy and Wounds Healing

Niu Niu, Na Yang, Cong Yu, Dong Wang, Ben Zhong Tang

ACS Materials Letters· Volume 4· Issue 4
Publisher page

Abstract

Bacterial infection is a worldwide issue seriously threatening human health. Construction of a multifunctional system with effective and synergistic antimicrobial therapy is an appealing yet significantly challenging task. Herein, we develop a smart light-responsive drug-delivery hybrid hydrogel, namely, TMH@Gel, with near-infrared-II (NIR-II) absorbing function, high photothermal conversion, and efficient chemodynamic capability. Antimicrobial evaluations demonstrate that TMH@Gel exhibits excellent antibacterial efficiency toward both Gram-negative and -positive bacteria upon NIR-II light irradiation, by means of synergistic photothermal–chemodynamic treatment. Moreover, the explored protocol can significantly accelerate the bacteria-infected wound healing process, strongly suggesting the prominent antibacterial performance. Furthermore, the good biocompatibility of TMH@Gel is verified by hemolysis assay and live/dead cell staining tests.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Nanoplatforms for cancer theranostics · Corneal Surgery and Treatments · Advanced Nanomaterials in Catalysis

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Center for AIE Research, Shenzhen Key Laboratory of Polymer Science and Technology, Guangdong Research Center for Interfacial Engineering of Functional Materials, College of Material Science and Engineering, Shenzhen University, Shenzhen 518060, China

College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China

State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China

University of Science and Technology of China, Hefei 230026, China

Shenzhen Institute of Molecular Aggregate Science and Engineering, School of Science and Engineering, The Chinese University of Hong Kong, Shenzhen, 2001 Longxiang Boulevard, Longgang District, Shenzhen City, Guangdong 518172, China

Funding

Science and Technology Foundation of Shenzhen City · National Natural Science Foundation of China · Natural Science Foundation of Guangdong Province

References (51)

Show source-provided references
1. 10.1002/phar.186810.1002/phar.1868 ↗
2. 10.1126/science.aam833510.1126/science.aam8335 ↗
3. 10.1146/annurev.biochem.78.082907.14592310.1146/annurev.biochem.78.082907.145923 ↗
4. 10.1093/cid/cix24610.1093/cid/cix246 ↗
5. 10.1002/cmdc.20210049410.1002/cmdc.202100494 ↗
6. 10.1016/j.ica.2021.12038110.1016/j.ica.2021.120381 ↗
7. 10.1039/C7CS00522A10.1039/C7CS00522A ↗
8. 10.1021/acsnano.0c1038810.1021/acsnano.0c10388 ↗
9. 10.1002/adma.20200321010.1002/adma.202003210 ↗
10. 10.1039/C8CS00618K10.1039/C8CS00618K ↗
11. 10.1002/adma.20190785510.1002/adma.201907855 ↗
12. 10.1002/anie.20181054110.1002/anie.201810541 ↗
13. 10.1002/smll.20190264710.1002/smll.201902647 ↗
14. 10.1021/acsami.0c1323710.1021/acsami.0c13237 ↗
15. 10.1039/D0CS00664E10.1039/D0CS00664E ↗
16. 10.1002/adma.20190736510.1002/adma.201907365 ↗
17. 10.1002/anie.20211176710.1002/anie.202111767 ↗
18. 10.1021/ja508641z10.1021/ja508641z ↗
19. 10.1016/j.biomaterials.2019.11930410.1016/j.biomaterials.2019.119304 ↗
20. 10.1002/anie.20191025710.1002/anie.201910257 ↗
21. 10.1002/anie.20170897110.1002/anie.201708971 ↗
22. 10.1021/ar400264e10.1021/ar400264e ↗
23. 10.1002/adma.20090378310.1002/adma.200903783 ↗
24. 10.1021/acs.analchem.9b0152710.1021/acs.analchem.9b01527 ↗
25. 10.1038/s41467-018-03903-810.1038/s41467-018-03903-8 ↗
26. 10.1007/s12274-018-2175-910.1007/s12274-018-2175-9 ↗
27. 10.1021/acsnano.8b0763510.1021/acsnano.8b07635 ↗
28. 10.1002/adma.20180827810.1002/adma.201808278 ↗
29. 10.1002/adma.20170168310.1002/adma.201701683 ↗
30. 10.1002/anie.20171202710.1002/anie.201712027 ↗
31. 10.1039/C6TB03146C10.1039/C6TB03146C ↗
32. 10.1021/acsnano.8b0509010.1021/acsnano.8b05090 ↗
33. 10.1016/j.carbon.2019.11.09310.1016/j.carbon.2019.11.093 ↗
34. 10.1002/advs.20190257610.1002/advs.201902576 ↗
35. 10.1038/s41467-019-12313-310.1038/s41467-019-12313-3 ↗
36. 10.1021/acsnano.1c0089410.1021/acsnano.1c00894 ↗
37. 10.1039/C8TB03272F10.1039/C8TB03272F ↗
38. 10.1073/pnas.171442111510.1073/pnas.1714421115 ↗
39. 10.1016/j.cej.2020.12445010.1016/j.cej.2020.124450 ↗
40. 10.1021/ac60103a04210.1021/ac60103a042 ↗
41. 10.1016/j.gene.2018.03.08210.1016/j.gene.2018.03.082 ↗
42. 10.1039/C5TB00413F10.1039/C5TB00413F ↗
43. 10.1021/jp802604d10.1021/jp802604d ↗
44. 10.1016/0368-2048(92)80047-C10.1016/0368-2048(92)80047-C ↗
45. 10.1021/jacs.8b0871410.1021/jacs.8b08714 ↗
46. 10.1021/ja406820f10.1021/ja406820f ↗
47. 10.1021/acsbiomaterials.7b0056910.1021/acsbiomaterials.7b00569 ↗
48. 10.1021/ac301212610.1021/ac3012126 ↗
49. 10.1021/acsnano.0c0385510.1021/acsnano.0c03855 ↗
50. 10.1021/acsnano.9b0560810.1021/acsnano.9b05608 ↗
51. 10.1039/D0TB00361A10.1039/D0TB00361A ↗