Macrocycle-Based Polymer Nanocapsules for Hypoxia-Responsive Payload Delivery
Source abstract
Abstract
Hypoxia is a typical hallmark in several disease conditions, particularly in solid tumors. Thus, hypoxia-responsive nanocarriers that may specifically deliver and release payload under hypoxic conditions have been highly sought after, for precision medicine. Herein, we report the first hypoxia-responsive, covalently self-assembled polymer nanocapsules (NCs), formed via directly crosslinking perhydroxycucurbit[6]uril with a ditopic, hypoxia-responsive azobenzene derivative (AZO). Because of the presence of macrocyclic cucurbit[6]uril, the hypoxia-responsive nanocapsules (AZO-NCs) allowed modular, noncovalent surface functionalization. As a proof-of-concept, folate-functionalized AZO-NCs exhibited targeted payload delivery into cancer cells, and more importantly, hypoxia-responsive payload release was validated both in vitro and in vivo.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Nanoplatforms for cancer theranostics · Supramolecular Chemistry and Complexes · Luminescence and Fluorescent Materials
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Avenida da Universidade, Taipa, Macau SAR 999078, China
Funding
Universidade de Macau · Fundo para o Desenvolvimento das Ci?ncias e da Tecnologia · National Natural Science Foundation of China
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