journal article·2022-01-03

Deep-Red Aggregation-Induced Emission Luminogen Based on Dithiofuvalene-Fused Benzothiadiazole for Lipid Droplet-Specific Imaging

Ying Yu, Hao Xing, Hojeong Park, Ruoyao Zhang, Chen Peng, Herman H.-Y. Sung, Ian D. Williams, Chao Ma, Kam Sing Wong, Shijie Li, Qingping Xiong, Min-Hui Li, Zheng Zhao, Ben Zhong Tang

ACS Materials Letters· Volume 4· Issue 1
Publisher page

Abstract

Lipid droplets (LDs) actively participate in many biological processes whose abnormality will result in different diseases; thus, it is vital to study the bioactivities of LDs. Red/near-infrared (NIR) fluorescent materials with aggregation-induced emission (AIE) characteristics are suitable for LD imaging and tracking because of their noninvasiveness, large Stokes shift, low photodamage, and excellent photostability. Meanwhile, two-photon imaging emerges with advantages of higher resolution and deeper penetration depth. In this work, a new acceptor core, benzothiadiazol-7-ylidene malononitrile (BSM), is proposed to construct a deep-red AIE luminogen (AIEgen) with a D–A structure. The AIEgen shows a high solid-state quantum yield of 13%, whose emission spectrum covers the visible and NIR I region. Furthermore, this molecule exhibits an excellent two-photon imaging performance and high specificity toward lipid droplets in all levels of biosubstances, including cells, tissues, and living zebrafish embryos, showing high potential for LD imaging and tracking in biomedical research.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Luminescence and Fluorescent Materials · Mass Spectrometry Techniques and Applications · Lipid metabolism and biosynthesis

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Shenzhen Institute of Molecular Aggregate Science and Engineering, School of Science and Engineering, The Chinese University of Hong Kong, Shenzhen 518172, China

Department of Chemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong 999077, China

Department of Physics, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong 999077, China

Guangdong Provincial Key Laboratory of New Drug Development and Research of Chinese Medicine, Mathematical Engineering Academy of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510006, China

Chimie ParisTech, PSL University Paris, CNRS, Institut de Recherche de Chimie Paris, 75005 Paris, France

Funding

Research Grants Council, University Grants Committee · Innovation and Technology Commission · National Natural Science Foundation of China

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