Restoration of Motor and Bladder Functions after Spinal Cord Injury via Sustained Wogonin Release from Carbon Nanotube Incorporated Hydrogels
Source abstract
Abstract
Spinal cord injury (SCI) results in structural and neural cell damage, leading to motor and bladder dysfunction. The limited regenerative capabilities and SCI-mediated inflammation exacerbate secondary damage and impede neurological recovery. To enhance neural regeneration and modulate inflammatory responses, a dual-functional scaffold with electrical properties and sustained release of wogonin (Wog), an ingredient in Chinese herbal medicines, was developed. With incorporation of Wog-loaded carbon nanotubes into photo-cross-linkable gelatin hydrogel, improvements in electrical conductivity and mechanical properties and sustained Wog release behavior of the functional hydrogel enhanced migration and neurogenic differentiation of neural stem cells and vascularization and suppressed pro-inflammatory responses and fibrosis in damaged spinal cord and detrusor and sphincter muscles of bladder, consequently accelerating motor and neurogenic lower urinary tract function recovery. Our work presents a novel strategy for addressing motor and bladder dysfunction after SCI, focusing on promoting neural regeneration and modulating the inflammatory microenvironment.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Neurological Disorders and Treatments · Flavonoids in Medical Research · Proteoglycans and glycosaminoglycans research
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Orthopedic Surgery, Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine, Nanjing 210008, China
Key Laboratory for Nano-Bio Interface Research, Division of Nanobiomedicine, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou 215123, China
The Second Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210017, China
State Key Laboratory of Molecular Development Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China
Tianjin Key Laboratory of Biomedical Materials, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300192, China
School of Nano-Tech and Nano-Bionics, University of Science and Technology of China, Hefei 230026, China
Funding
National Key Research and Development Program of China · Youth Innovation Promotion Association of the Chinese Academy of Sciences
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