DataVXACS Materials LettersPaper
journal article·2025-05-05

Defect-Engineered CoFe Layered Double Hydroxide Quantum Dots: Oxygen Vacancy-Driven Boost in Peroxidase-Mimic Catalysis for Multiplex Biomarker Sensing

Zhongwei Yang, Xiaoyu Zhang, Longwei Wang, Jian Zhang, Na Ren, Longhua Ding, Shenghao Xu, Zheng Wang, Aizhu Wang, Hong Liu, Xin Yu

ACS Materials Letters· Volume 7· Issue 5
Publisher page
Source abstract

Abstract

Defects in nanomaterials are crucial for modifying the catalytic microenvironment, thus enhancing nanozyme catalytic efficiency. Combining defect engineering with layered double hydroxides (LDHs) nanozymes holds promise for expanding catalytic applications. We employed density functional theory (DFT) to systematically study how O vacancies regulate the peroxidase (POD)-like activity of CoFe LDHs nanozymes. Results show that O vacancies significantly alter the catalyst’s surface electronic configuration, optimize the adsorption energy of reactants, lower the reaction energy barrier, and boost POD activity. We synthesized O-vacancy-rich CoFe LDHs quantum dots, verified their excellent catalytic activity, and constructed a sensitive colorimetric detection platform for glucose, glutathione, and nitrite, enabling on-site detection via smartphone integration. This study offers an efficient and cost-effective solution for multiplex biomarker detection, laying the foundation for personalized medicine and point-of-care diagnostics.
Source: openalex_inverted_index · Quality: baseline

Research context

NanomaterialsCatalysis & surfaces

OpenAlex topics: Advanced Nanomaterials in Catalysis · Electrochemical sensors and biosensors · Advanced biosensing and bioanalysis techniques

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Institute for Advanced Interdisciplinary Research (iAIR), School of Chemistry and Chemical Engineering

University of Jinan

CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety and CAS Center for Excellence in Nanoscience

National Center for Nanoscience and Technology of China

Division of Systems and Synthetic Biology, Department of Life Sciences

Chalmers University of Technology

Key Laboratory of Optic-electric Sensing and Analytical Chemistry for Life Science, MOE, College of Chemistry and Molecular Engineering

Qingdao University of Science and Technology

Department of Applied Chemistry, School of Advanced Materials and Nanotechnology

Xidian University

State Key Laboratory of Crystal Material

Shandong University

Funding

China Postdoctoral Science Foundation · Taishan Scholar Foundation of Shandong Province · National Natural Science Foundation of China · Natural Science Foundation of Shandong Province

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