Bacterial Programmed Cell Death Induced by Nanotherapeutic Strategies
Source abstract
Abstract
Programmed cell death (PCD) is crucial for cell renewal, embryogenesis, the immune response, tissue growth regulation, and other essential biological processes. Recent evidence underscores the potential of harnessing PCD to combat bacterial infections, particularly in eradicating antibiotic-resistant superbugs. Extensive efforts have been devoted to developing PCD-mediated anti-infective agents by drawing insights from materials science, chemistry, immunology, and microbiology. In this review, the challenges in addressing bacterial infections and the potential of PCD-based approaches to revolutionize treatment are first summarized and discussed. Then, a comprehensive examination of PCD-mediated nanoantibacterial therapy, encompassing various pathways, such as bacterial apoptosis, ferroptosis, cuproptosis, immunogenic cell death, NETosis, autophagy, and pyroptosis, is provided. Finally, the barriers and prospects of PCD-driven antimicrobial strategies are explored.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Bacterial biofilms and quorum sensing · Nanoplatforms for cancer theranostics · Nanoparticle-Based Drug Delivery
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
College of Life and Health, Nanjing Polytechnic Institute, Nanjing 210048, China
Key Laboratory of Flexible Electronics (KLOFE) and Institute of Advanced Materials (IAM), School of Physical and Mathematical Sciences, Nanjing Tech University (NanjingTech), Nanjing 211816, China
Nanjing Stomatological Hospital, Affiliated Hospital of Medical School, Institute of Stomatology, Nanjing University, 30 Zhongyang Road, Nanjing, Jiangsu 210008, China
Funding
Qinglan Project of Jiangsu Province of China · Natural Science Foundation of Jiangsu Province · National Natural Science Foundation of China · Nanjing Clinical Research Center for Oral Diseases · Natural Science Research Project of Nanjing Polytechnic Institute
References (100+)
Show source-provided references
1. 10.1016/j.actbio.2024.02.00510.1016/j.actbio.2024.02.005 ↗
2. 10.1038/s41528-024-00312-410.1038/s41528-024-00312-4 ↗
3. 10.1038/s41579-022-00686-010.1038/s41579-022-00686-0 ↗
4. 10.1038/s41590-023-01660-510.1038/s41590-023-01660-5 ↗
5. 10.1186/s12985-017-0849-710.1186/s12985-017-0849-7 ↗
6. 10.1002/EXP.2023008710.1002/EXP.20230087 ↗
7. 10.1002/smll.20240272310.1002/smll.202402723 ↗
8. 10.1016/j.jconrel.2007.10.02710.1016/j.jconrel.2007.10.027 ↗
9. 10.1002/anie.20231387010.1002/anie.202313870 ↗
10. 10.34133/2020/942645310.34133/2020/9426453 ↗
11. 10.1016/j.cis.2024.10307810.1016/j.cis.2024.103078 ↗
12. 10.1016/j.cej.2020.12720010.1016/j.cej.2020.127200 ↗
13. 10.1146/annurev-biochem-060614-03451610.1146/annurev-biochem-060614-034516 ↗
14. 10.1002/smll.20230412710.1002/smll.202304127 ↗
15. 10.1021/acsabm.2c0019910.1021/acsabm.2c00199 ↗
16. 10.1146/annurev-pathmechdis-051022-01443310.1146/annurev-pathmechdis-051022-014433 ↗
17. 10.1038/cddis.2014.57010.1038/cddis.2014.570 ↗
18. 10.1111/2049-632X.1214510.1111/2049-632X.12145 ↗
19. 10.1016/j.micres.2017.11.01610.1016/j.micres.2017.11.016 ↗
20. 10.1016/j.tim.2013.04.00110.1016/j.tim.2013.04.001 ↗
21. 10.1016/j.tim.2012.02.00510.1016/j.tim.2012.02.005 ↗
22. 10.1111/cmi.1257310.1111/cmi.12573 ↗
23. 10.1038/cdd.2008.9110.1038/cdd.2008.91 ↗
24. 10.1038/nri.2016.14710.1038/nri.2016.147 ↗
25. 10.1186/s40824-023-00405-710.1186/s40824-023-00405-7 ↗
26. 10.1038/s41579-020-0420-110.1038/s41579-020-0420-1 ↗
27. 10.1016/j.nantod.2022.10160210.1016/j.nantod.2022.101602 ↗
28. 10.1002/smll.20220622010.1002/smll.202206220 ↗
29. 10.53388/BMEC202300210.53388/BMEC2023002 ↗
30. 10.1039/D2BM01489K10.1039/D2BM01489K ↗
31. 10.1002/wnan.177510.1002/wnan.1775 ↗
32. 10.1016/j.ejps.2023.10651510.1016/j.ejps.2023.106515 ↗
33. 10.1038/nrmicro313610.1038/nrmicro3136 ↗
34. 10.1038/s41416-022-02020-010.1038/s41416-022-02020-0 ↗
35. 10.1002/cbin.1113710.1002/cbin.11137 ↗
36. 10.1039/D3EN00176H10.1039/D3EN00176H ↗
37. 10.1002/smtd.20210130410.1002/smtd.202101304 ↗
38. 10.1111/jam.1435710.1111/jam.14357 ↗
39. 10.1371/journal.pone.012253510.1371/journal.pone.0122535 ↗
40. 10.2147/IJN.S11774510.2147/IJN.S117745 ↗
41. 10.1039/D1BM00457C10.1039/D1BM00457C ↗
42. 10.1016/j.biomaterials.2021.12091810.1016/j.biomaterials.2021.120918 ↗
43. 10.1039/D1NR02881B10.1039/D1NR02881B ↗
44. 10.34133/2022/978087910.34133/2022/9780879 ↗
45. 10.1016/j.nantod.2021.10122910.1016/j.nantod.2021.101229 ↗
46. 10.1002/EXP.2021011710.1002/EXP.20210117 ↗
47. 10.1002/adma.20190419710.1002/adma.201904197 ↗
48. 10.1016/j.matt.2023.01.03310.1016/j.matt.2023.01.033 ↗
49. 10.1038/s41419-020-03194-210.1038/s41419-020-03194-2 ↗
50. 10.1186/s12943-022-01530-y10.1186/s12943-022-01530-y ↗
51. 10.1016/j.biomaterials.2022.12194410.1016/j.biomaterials.2022.121944 ↗
52. 10.3390/polym907026710.3390/polym9070267 ↗
53. 10.1002/pola.2802410.1002/pola.28024 ↗
54. 10.1002/med.2200310.1002/med.22003 ↗
55. 10.1016/j.nantod.2020.10098110.1016/j.nantod.2020.100981 ↗
56. 10.1080/10717544.2022.215213410.1080/10717544.2022.2152134 ↗
57. 10.1021/acsnano.2c1096010.1021/acsnano.2c10960 ↗
58. 10.1039/D0BM01290D10.1039/D0BM01290D ↗
59. 10.1021/acsami.8b1572410.1021/acsami.8b15724 ↗
60. 10.1021/acsnano.3c0236510.1021/acsnano.3c02365 ↗
61. 10.1002/ajh.2453110.1002/ajh.24531 ↗
62. 10.1016/j.cell.2016.12.03410.1016/j.cell.2016.12.034 ↗
63. 10.2147/IJN.S38292810.2147/IJN.S382928 ↗
64. 10.1002/advs.20220750710.1002/advs.202207507 ↗
65. 10.1002/adhm.20230041010.1002/adhm.202300410 ↗
66. 10.1126/science.abf052910.1126/science.abf0529 ↗
67. 10.1016/j.cej.2023.14495110.1016/j.cej.2023.144951 ↗
68. 10.1002/adfm.20230819710.1002/adfm.202308197 ↗
69. 10.1084/jem.2005091510.1084/jem.20050915 ↗
70. 10.1038/s41418-017-0012-410.1038/s41418-017-0012-4 ↗
71. 10.1002/advs.20230133910.1002/advs.202301339 ↗
72. 10.1002/adfm.20247014110.1002/adfm.202470141 ↗
73. 10.34133/research.019810.34133/research.0198 ↗
74. 10.1002/adma.20210730010.1002/adma.202107300 ↗
75. 10.1016/j.micinf.2007.11.00710.1016/j.micinf.2007.11.007 ↗
76. 10.1182/blood-2006-10-05422110.1182/blood-2006-10-054221 ↗
77. 10.1242/dmm.04941410.1242/dmm.049414 ↗
78. 10.1016/j.smim.2023.10180510.1016/j.smim.2023.101805 ↗
79. 10.1016/j.jare.2023.09.01810.1016/j.jare.2023.09.018 ↗
80. 10.2174/138161282966623020114402910.2174/1381612829666230201144029 ↗
81. 10.1016/j.cej.2023.14764510.1016/j.cej.2023.147645 ↗
82. 10.1016/j.actbio.2023.06.02510.1016/j.actbio.2023.06.025 ↗
83. 10.1080/15548627.2020.171420910.1080/15548627.2020.1714209 ↗
84. 10.1002/anie.20201322810.1002/anie.202013228 ↗
85. 10.1016/j.jbc.2023.10546310.1016/j.jbc.2023.105463 ↗
86. 10.7150/thno.6666310.7150/thno.66663 ↗
87. 10.1021/acsnano.3c0076510.1021/acsnano.3c00765 ↗
88. 10.1002/adma.20230527710.1002/adma.202305277 ↗
89. 10.3389/fphar.2022.93813410.3389/fphar.2022.938134 ↗
90. 10.1038/s41420-022-01164-510.1038/s41420-022-01164-5 ↗
91. 10.1021/acs.chemrev.3c0016110.1021/acs.chemrev.3c00161 ↗
92. 10.1002/adma.20230343210.1002/adma.202303432 ↗
93. 10.1016/j.nantod.2023.10209210.1016/j.nantod.2023.102092 ↗
94. 10.1002/mco2.16210.1002/mco2.162 ↗
95. 10.1002/adma.20230811010.1002/adma.202308110 ↗
96. 10.1002/adhm.20230098510.1002/adhm.202300985 ↗
97. 10.1126/science.109238510.1126/science.1092385 ↗
98. 10.1016/j.actbio.2022.08.06610.1016/j.actbio.2022.08.066 ↗
99. 10.1002/adfm.20221181110.1002/adfm.202211811 ↗
100. 10.1111/j.1365-2184.2012.00845.x10.1111/j.1365-2184.2012.00845.x ↗