journal article·2024-05-06

MXBOTs: Biodegradable Ti3C2 MXene-Based Microrobots for Targeted Delivery and Synergistic Chemo-Photothermal Therapy

Ming Yang, Hanhan Xie, Tiancheng Jiang, Zhen Zhan, Min Ye, Tao Yue, Xiaohui Yan, Xiaopu Wang, Chengzhi Hu

ACS Materials Letters· Volume 6· Issue 5
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Abstract

Functions such as biocompatibility, degradability, therapeutics, and imaging are critical for use of microrobots in clinical scenarios; however, incorporation of these functions into a single microrobotic entity is still challenging. Herein, we report multifunctional Ti 3 C 2 MXene-based magnetically actuated microrobots (MXBOTs), which are prepared by sequentially electrostatic coating of Ti 3 C 2 nanosheets and Fe 3 O 4 nanoparticles on the surface of biodegradable gelatin methacryloyl (GelMA)-based helical microstructures. These MXBOTs can move along predefined paths under a rotating magnetic field. The incorporation of Ti 3 C 2 nanosheets provides MXBOTs with an advantageous photothermal effect and photoacoustic (PA) imaging capability. Additionally, MXBOTs can be loaded with fluorescent molecules, enabling fluorescence imaging. After loading the chemotherapeutic drug DOX, the MXBOTs@DOX were able to accelerate the release of DOX under the stimulation of temperature and acidic pH. This work presents a viable approach for developing biodegradable and functional microrobots for targeted delivery and synergistic chemo-photothermal therapy.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Micro and Nano Robotics · MXene and MAX Phase Materials · Nanoplatforms for cancer theranostics

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

School of Mechatronics Engineering, Harbin Institute of Technology, Harbin 150001, China

Shenzhen Key Laboratory of Biomimetic Robotics and Intelligent Systems, Department of Mechanical and Energy Engineering, Southern University of Science and Technology, Shenzhen 518055, China

State Key Laboratory of Vaccines for Infectious Diseases, School of Public Health, Xiamen University, Xiamen 361005, China

Shenzhen Institute of Artificial Intelligence and Robotics for Society, Shenzhen, Guangdong 518129, China

School of Mechatronics Engineering and Automation, Shanghai University, Shanghai 200444, China

Guangdong Provincial Key Laboratory of Human-Augmentation and Rehabilitation Robotics in Universities, Southern University of Science and Technology, Shenzhen 518055, China

Funding

Natural Science Foundation of Shanghai Municipality · Science and Technology Planning Project of Guangdong Province · National Key Research and Development Program of China · Natural Science Foundation of Shenzhen Municipality · Science, Technology and Innovation Commission of Shenzhen Municipality · National Natural Science Foundation of China

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