journal article·2024-03-04

Transdermal Drug Delivery System: Current Status and Clinical Application of Microneedles

Yanan Xue, Cheng Chen, Xiangyu Mi, Rong Tan, Ji Wang, Sufan Wu, Yue Wang, Rong Xiong, Mengxiao Chen, Wei-Qiang Tan, Haojian Lu

ACS Materials Letters· Volume 6· Issue 3
Publisher page

Abstract

As a new type of transdermal drug delivery system (TDDS), microneedles have garnered significant attention for their noninvasiveness, portability, controllable drug administration, and wide-ranging loading capacity. While initially designed for transdermal administration via the stratum corneum for minimizing adverse reactions associated with systemic administration and enhancing patient compliance, microneedles have recently found applications in a multitude of medical contexts. Hence, their potential in medical applications transcends mere drug delivery. Recent reviews on microneedles have extensively covered various aspects, including needle types, materials, and manufacturing methods, as well as their applications in treating skin diseases. This review aims to provide a comprehensive overview of the diverse designs and applications of microneedles from different new perspectives, which encompass traditional integrated microneedles as well as more intelligent and structurally optimized ones in nowadays. Additionally, this review offers a comprehensive analysis of the material properties utilized in microneedles for different applications, including nondegradable materials and degradable materials. Furthermore, the review presents the wide-ranging applications of these microneedles in different medical scenarios such as regeneration and repair, disease treatment, monitoring, and prevention. Moreover, the discussion of the article highlights the future clinical applications of microneedles and the necessary efforts required to achieve their widespread adoption. This review serves as a valuable reference for bridging the gap between the laboratory setting and the clinical practice in terms of using microneedles in medical scenarios.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Advancements in Transdermal Drug Delivery · Advanced Drug Delivery Systems · Dermatology and Skin Diseases

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Center for Plastic & Reconstructive Surgery, Department of Plastic & Reconstructive Surgery, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital, Hangzhou Medical College), Hangzhou, Zhejiang 310014, China

Huadong Industrial Technology Institute of Synthetic Biology, Hangzhou 310014, China

Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province, Hangzhou 310000, China

Institute of Cyber-Systems and Control, the Department of Control Science and Engineering, Zhejiang University, Hangzhou 310027, China

State Key Laboratory of Industrial Control and Technology, Zhejiang University, Hangzhou 310027, China

The Department of Electronic and Computer Engineering, Research Center on Smart Manufacturing, Hong Kong University of Science and Technology, Kowloon, Hong Kong 999077, China

Research Center for Humanoid Sensing, Zhejiang Lab 311100, Zhejiang Lab Nanhu Headquarters, Kechuang Avenue, Zhongtai Sub-District, Yuhang District, Hangzhou, Zhejiang Province 311121, P.R. China

Department of Plastic Surgery, Sir Run Run Shaw Hospital, Zhejiang University of Medicine, Hangzhou 310016, Zhejiang Province, China

Funding

Fundamental Research Funds for the Provincial Universities of Zhejiang · Major Scientific Project of Zhejiang Laboratory · Key Research and Development Program of Zhejiang Province · National Natural Science Foundation of China · Natural Science Foundation of Zhejiang Province · Science and Technology on Space Intelligent Control Laboratory

References (100+)

Show source-provided references
1. 10.1038/nbt.150410.1038/nbt.1504 ↗
2. 10.1016/j.jconrel.2014.04.04510.1016/j.jconrel.2014.04.045 ↗
3. 10.3109/10717544.2014.93553210.3109/10717544.2014.935532 ↗
4. 10.1016/j.jconrel.2022.09.02510.1016/j.jconrel.2022.09.025 ↗
5. 10.2174/138161282166615042812440610.2174/1381612821666150428124406 ↗
6. 10.1002/wnan.121110.1002/wnan.1211 ↗
7. 10.1016/j.actbio.2017.01.05710.1016/j.actbio.2017.01.057 ↗
8. 10.1111/j.0022-202X.2005.23668.x10.1111/j.0022-202X.2005.23668.x ↗
9. 10.1046/j.1523-1747.2003.12359.x10.1046/j.1523-1747.2003.12359.x ↗
10. 10.1016/j.bbamem.2006.06.02110.1016/j.bbamem.2006.06.021 ↗
11. 10.1111/j.1365-4362.1984.tb04061.x10.1111/j.1365-4362.1984.tb04061.x ↗
12. 10.1080/17425247.2020.170022610.1080/17425247.2020.1700226 ↗
13. 10.3390/pharmaceutics704043810.3390/pharmaceutics7040438 ↗
14. 10.1517/17425247.2012.67603810.1517/17425247.2012.676038 ↗
15. 10.1016/S0928-0987(01)00167-110.1016/S0928-0987(01)00167-1 ↗
16. 10.1016/j.jconrel.2014.05.02210.1016/j.jconrel.2014.05.022 ↗
17. 10.2147/IJN.S17475910.2147/IJN.S174759 ↗
18. 10.1517/17425247.3.1.12710.1517/17425247.3.1.127 ↗
19. 10.4155/tde.15.6110.4155/tde.15.61 ↗
20. 10.4155/tde-2020-012210.4155/tde-2020-0122 ↗
21. 10.1088/0957-4484/19/18/18510210.1088/0957-4484/19/18/185102 ↗
22. 10.7150/thno.6999910.7150/thno.69999 ↗
23. 10.1111/ddg.1296310.1111/ddg.12963 ↗
24. 10.1016/j.jconrel.2011.01.00610.1016/j.jconrel.2011.01.006 ↗
25. 10.1002/adma.20230006610.1002/adma.202300066 ↗
26. 10.2174/15672011079101176510.2174/156720110791011765 ↗
27. 10.1007/978-1-4939-0363-4_110.1007/978-1-4939-0363-4_1 ↗
28. 10.1038/nrd130410.1038/nrd1304 ↗
29. 10.1016/j.jconrel.2020.09.01610.1016/j.jconrel.2020.09.016 ↗
30. 10.1016/j.addr.2021.11391910.1016/j.addr.2021.113919 ↗
31. 10.1111/j.1751-1097.2008.00417.x10.1111/j.1751-1097.2008.00417.x ↗
32. 10.1016/j.ijpharm.2010.01.02410.1016/j.ijpharm.2010.01.024 ↗
33. 10.1007/s11095-007-9286-410.1007/s11095-007-9286-4 ↗
34. 10.1007/s10558-010-9100-510.1007/s10558-010-9100-5 ↗
35. 10.1016/j.carbpol.2021.11816810.1016/j.carbpol.2021.118168 ↗
36. 10.1002/bit.2818610.1002/bit.28186 ↗
37. 10.1039/D1TB00512J10.1039/D1TB00512J ↗
38. 10.1016/j.jconrel.2022.05.04510.1016/j.jconrel.2022.05.045 ↗
39. 10.1002/mabi.20217000310.1002/mabi.202170003 ↗
40. 10.1016/j.apsb.2021.02.01010.1016/j.apsb.2021.02.010 ↗
41. 10.1002/adhm.20180118010.1002/adhm.201801180 ↗
42. 10.1016/j.actbio.2020.12.00410.1016/j.actbio.2020.12.004 ↗
43. 10.1021/acsami.2c0899410.1021/acsami.2c08994 ↗
44. 10.1002/adhm.20200052710.1002/adhm.202000527 ↗
45. 10.1002/btm2.1015710.1002/btm2.10157 ↗
46. 10.1016/j.actbio.2022.08.06110.1016/j.actbio.2022.08.061 ↗
47. 10.1002/adfm.20211074610.1002/adfm.202110746 ↗
48. 10.1002/adfm.20190919710.1002/adfm.201909197 ↗
49. 10.34133/2020/367212010.34133/2020/3672120 ↗
50. 10.1016/j.cej.2021.13336210.1016/j.cej.2021.133362 ↗
51. 10.1021/acsnano.1c0627910.1021/acsnano.1c06279 ↗
52. 10.1021/acs.nanolett.1c0457310.1021/acs.nanolett.1c04573 ↗
53. 10.1073/pnas.150540511210.1073/pnas.1505405112 ↗
54. 10.1021/acs.nanolett.6b0384810.1021/acs.nanolett.6b03848 ↗
55. 10.1038/s41551-019-0508-y10.1038/s41551-019-0508-y ↗
56. 10.1021/acs.nanolett.5b0503010.1021/acs.nanolett.5b05030 ↗
57. 10.1021/acsnano.0c0105910.1021/acsnano.0c01059 ↗
58. 10.1021/acsnano.1c0622510.1021/acsnano.1c06225 ↗
59. 10.1016/j.actbio.2018.09.00710.1016/j.actbio.2018.09.007 ↗
60. 10.1016/j.ijpharm.2018.12.08910.1016/j.ijpharm.2018.12.089 ↗
61. 10.1007/s13346-020-00782-910.1007/s13346-020-00782-9 ↗
62. 10.1038/srep2142210.1038/srep21422 ↗
63. 10.18063/ijb.v8i2.55310.18063/ijb.v8i2.553 ↗
64. 10.1016/j.biomaterials.2015.08.04510.1016/j.biomaterials.2015.08.045 ↗
65. 10.3389/fbioe.2022.90760110.3389/fbioe.2022.907601 ↗
66. 10.1016/j.biomaterials.2019.01.01110.1016/j.biomaterials.2019.01.011 ↗
67. 10.1016/j.jconrel.2005.02.00210.1016/j.jconrel.2005.02.002 ↗
68. 10.4155/tde.14.9110.4155/tde.14.91 ↗
69. 10.2174/138955752266622012815284710.2174/1389557522666220128152847 ↗
70. 10.1002/adma.20200212910.1002/adma.202002129 ↗
71. 10.1039/D1BM01249E10.1039/D1BM01249E ↗
72. 10.3390/pharmaceutics1501027710.3390/pharmaceutics15010277 ↗
73. 10.1021/acs.biomac.1c0121310.1021/acs.biomac.1c01213 ↗
74. 10.1021/acsami.3c0680010.1021/acsami.3c06800 ↗
75. 10.1021/acsnano.2c0306010.1021/acsnano.2c03060 ↗
76. 10.1002/adma.20221090310.1002/adma.202210903 ↗
77. 10.1002/adfm.20210409210.1002/adfm.202104092 ↗
78. 10.1021/acs.analchem.3c0224210.1021/acs.analchem.3c02242 ↗
79. 10.1002/smll.20220306410.1002/smll.202203064 ↗
80. 10.1021/acsnano.1c1101610.1021/acsnano.1c11016 ↗
81. 10.1021/acsnano.2c0897910.1021/acsnano.2c08979 ↗
82. 10.1016/j.matt.2021.11.01710.1016/j.matt.2021.11.017 ↗
83. 10.1021/acsnano.1c0527210.1021/acsnano.1c05272 ↗
84. 10.1021/acs.nanolett.2c0225910.1021/acs.nanolett.2c02259 ↗
85. 10.1021/acsnano.1c0317710.1021/acsnano.1c03177 ↗
86. 10.1038/s41467-018-06981-w10.1038/s41467-018-06981-w ↗
87. 10.1126/sciadv.aba726010.1126/sciadv.aba7260 ↗
88. 10.1021/acsnano.2c0809810.1021/acsnano.2c08098 ↗
89. 10.1002/adma.20220864810.1002/adma.202208648 ↗
90. 10.1002/adma.20170224310.1002/adma.201702243 ↗
91. 10.1016/j.bios.2022.11441210.1016/j.bios.2022.114412 ↗
92. 10.1126/sciadv.160131410.1126/sciadv.1601314 ↗
93. 10.1038/s41551-022-00887-110.1038/s41551-022-00887-1 ↗
94. 10.1186/s13036-015-0001-410.1186/s13036-015-0001-4 ↗
95. 10.3390/jfb901001710.3390/jfb9010017 ↗
96. 10.1080/03091902.2021.189384510.1080/03091902.2021.1893845 ↗
97. 10.1002/adma.20160463010.1002/adma.201604630 ↗
98. Ventola C. L. · Pharmacy and Therapeutics · 2014 · 39 · 704
99. 10.1016/j.biomaterials.2023.12207510.1016/j.biomaterials.2023.122075 ↗
100. 10.1039/C8LC00510A10.1039/C8LC00510A ↗