Metallacages and Covalent Cages for Biological Imaging and Therapeutics
Source abstract
Abstract
Due to their precise three-dimensional structures and tunable cavities, metallacages and covalent cages have been widely used in various fields, such as catalysis, separation, sensing, and biomedicine. As a result of the unique pattern of directed synthesis and modular assembly, cages can be modified in many different ways to construct stimuli-responsive cages for marker detection and imaging in biological applications. Additionally, imaging agents and drugs can be loaded into the unique cavity of the cages to achieve precise disease diagnosis and treatment. This Review summarizes recent advances in metallacages and covalent cages in biological applications and presents their representative examples in imaging and therapeutics. The problems and future development directions of cages in biological applications are emphasized, which may provide clear guidance for the design and application of precise and controllable biological diagnostic reagents.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Supramolecular Chemistry and Complexes · Advanced biosensing and bioanalysis techniques · Supramolecular Self-Assembly in Materials
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Shanghai Key Laboratory of Green Chemistry and Chemical Processes, Shanghai Frontiers Science Center of Molecule Intelligent Syntheses, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, P. R. China
Wuhu Hospital, East China Normal University (The Second People’s Hospital of Wuhu), Wuhu 241001, P. R. China
Wuhu Hospital and Health Science Center, East China Normal University, Shanghai 200062, P. R. China
Funding
Central University Basic Research Fund of China · Science and Technology Commission of Shanghai Municipality · National Natural Science Foundation of China · Shanghai Key Laboratory of Green Chemistry and Chemical Processes, East China Normal University
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