DataVXACS Materials LettersPaper
journal article·2023-10-02

Natural Metal Polyphenol Nanozyme: Free Radical Scavenging and Antioxidation for the Treatment of Acute Kidney Injury

Haitao Yuan, Fujing Wang, Zhen Wang, Di Gu, Wei Huang, Chunjin Fu, Xiaoxian Wang, Jingbo Ma, Zhijie Li, Lingyun Dai, Xinzhou Zhang, Wei Xiao, Jigang Wang

ACS Materials Letters· Volume 5· Issue 10
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Source abstract

Abstract

Acute kidney injury (AKI) is a severe renal dysfunction syndrome associated with high morbidity and mortality. Excessive production of reactive oxygen/nitrogen species (RONS) is involved in the development and progression of AKI. Therefore, scavenging endogenous RONS and reducing excessive oxidative stress is essential for restoring renal function after AKI. Although nanozyme-mediated antioxidant therapy has been proposed as an effective strategy to prevent AKI, low renal uptake and high organ toxicity hinder its potential for practical applications. To address this problem, we have designed a metal-phenolic nanozyme named RosA-Mn NPs, which possesses cascade antioxidant functionalities. The nanozyme has multienzymatic cascade capacity as well as broad spectrum of ROS and free radical scavenging activities. As expected, RosA-Mn NPs promote the recovery of mitochondrial function and reduce endoplasmic reticulum stress and secondary inflammation through effective ROS scavenging in vitro. Moreover, RosA-Mn NPs overcome the shortcomings of artificial enzymes that failed to rapidly accumulate in kidney tissues. The renal tubular targeting of RosA-Mn NPs could be exploited to mitigate the tubular damage, improve tubular functions, and eventually prevent the progression of AKI. Notably, RosA-Mn NPs also protect kidney from oxidation and inflammation in a cisplatin-induced AKI mouse model. RNA sequencing analysis demonstrated that autophagy, apoptosis, and antioxidation-related pathways were modulated by the treatment with RosA-Mn NPs. In summary, the multienzymatic activities and biocompatibility of RosA-Mn NPs show great potential in the treatment of AKI and other ROS-related diseases.
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Research context

NanomaterialsBiomaterials

OpenAlex topics: Advanced Nanomaterials in Catalysis · Acute Kidney Injury Research

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Nephrology, Shenzhen People’s Hospital, The Second Clinical Medical College of Jinan University, Shenzhen 518020 , Guangdong, People’s Republic of China

Shenzhen Key Laboratory of Kidney Diseases, and Shenzhen Clinical Research Centre for Geriatrics, Shenzhen People’s Hospital, The First Affiliated Hospital, Southern University of Science and Technology, Shenzhen 518020, People’s Republic of China

Department of Traditional Chinese Medicine and School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, Guangdong 510515, People’s Republic of China

Guangdong Key Laboratory of Urology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510230, China

School of Chemical Engineering and Technology, Sun Yat-sen University, Zhuhai 519082, People’s Republic of China

State Key Laboratory for Quality Assurance and Sustainable Use of Dao-di Herbs, Artemisinin Research Center, and Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, People’s Republic of China

Department of Oncology, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, People’s Republic of China

Funding

National Key Research and Development Program of China · Science and Technology Foundation of Shenzhen City · Basic and Applied Basic Research Foundation of Guangdong Province · China Postdoctoral Science Foundation · Science, Technology and Innovation Commission of Shenzhen Municipality · Shenzhen key Laboratory of Kidney Diseases · Distinguished Expert Project of Sichuan Province Tianfu Scholar · International Science and Technology Cooperation for Shenzhen Technology Innovation Plan · Shenzhen Fund for Guangdong Provincial High- level Clinical Key Specialties

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