Remodeling Tumor Microenvironment by Multifunctional Nanoassemblies for Enhanced Photodynamic Cancer Therapy
Source abstract
Abstract
Photodynamic therapy (PDT) is a clinically implemented modality to tackle intractable diseases, including cancer. Nevertheless, its efficacy is largely compromised by some resistance factors from the complex tumor microenvironment (TME) with various biological barriers. Inspiringly, recent development in nanotechnology has revitalized photodynamic cancer therapy based on rationally designed nanoplatforms that can boost PDT through remodeling TME. Here, we first provide an overview of the microenvironment in solid tumors and the PDT-resistance factors therein. On this basis, we discuss strategies to design multifunctional nanoassemblies and underlying working mechanisms to enhance photodynamic cancer therapy by modulating tumor vasculatures, extracellular matrix, hypoxia, antioxidant defense, and immune suppression. Finally, we highlight the potential and challenges in this burgeoning research field.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Nanoplatforms for cancer theranostics · Photodynamic Therapy Research Studies · Advanced Nanomaterials in Catalysis
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Key Laboratory of Flexible Electronics (KLOFE) and Institute of Advanced Materials (IAM), Nanjing Tech University (NanjingTech), Nanjing 211800, China
Department of Biomedical Sciences, City University of Hong Kong, Hong Kong 999077, China
School of Physical Science and Information Technology, Liaocheng University, Liaocheng 252059, China
School of Chemical and Biomedical Engineering, Nanyang Technological University, 62 Nanyang Drive, 637459, Singapore
School of Chemistry and Materials Science, Nanjing University of Information Science & Technology, Nanjing 210044, China
Funding
Shandong Province · Government of Jiangsu Province · National Natural Science Foundation of China
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