journal article·2020-02-03

NIR-II Dye-Based Multifunctional Telechelic Glycopolymers for NIR-IIa Fluorescence Imaging-Guided Stimuli-Responsive Chemo-Photothermal Combination Therapy

Shangyu Chen, Bo Sun, Han Miao, Gaina Wang, Pengfei Sun, Jiewei Li, Wenjun Wang, Quli Fan, Wei Huang

ACS Materials Letters· Volume 2· Issue 2
Publisher page

Abstract

Optical imaging-guided chemo-photothermal combination therapy of cancers has attracted considerable attention, because of its capacity for personalized, precision treatment and its synergistic chemo-photothermal therapeutic effect. However, it still encounters many barriers, including an unsatisfactory diagnostic accuracy, poor physiological stability, low drug loading, and uncontrolled drug release. Here, we developed a NIR-II dye-based multifunctional telechelic glycopolymer (TTQ-TC-PFru) as a drug carrier and constructed stimuli-responsive PFru-BTZ-PBOB nanoparticles (NPs) to achieve the near-infrared IIa (NIR-IIa, 1300-1400 nm) fluorescence imaging (FI)-guided chemo-photothermal combination therapy of cancers. This multifunctional glycopolymer not only serves as the contrast agent for NIR-IIa FI but also functions as the photothermal agent for photothermal therapy (PTT). Meanwhile, the fructose polymer on TTQ-TC-PFru forms a stable boronic acid-catechol conjugate with the dipeptidyl boronic acid proteasome inhibitor bortezomib (BTZ) to achieve high drug loading (31%), satisfactory physiological stability, and controlled drug release in the acidic tumor microenvironment. In addition, one BOB-containing copolymer POEGMA-co-PBOB was introduced to further improve the stability of the system. In living tumor-bearing mice, the successfully constructed stimuli-responsive NPs PFru-BTZ-PBOB induced significant tumor regression through NIR-IIa FI-guided chemo-photothermal combination therapy. Our study thus describes the great potential of NIR-IIa FI-guided chemo-photothermal combination therapy of cancers.
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Research context

OpenAlex topics: Nanoplatforms for cancer theranostics · Nanoparticle-Based Drug Delivery · Advanced Nanomaterials in Catalysis

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Key Laboratory for Organic Electronics and Information Displays & Jiangsu Key Laboratory for Biosensors, Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing University of Posts & Telecommunications, 9 Wenyuan Road, Nanjing 210023, China

School of Materials Science and Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332, United States

Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing Tech University (NanjingTech), 30 South Puzhu Road, Nanjing 211816, China

Key Lab of Optical Communication Science and Technology of Shandong Province & School of Physics Science and Information Engineering, Liaocheng University, Liaocheng 252059, China

Key Laboratory for Organic Electronics and Information Displays &Jiangsu Key Laboratory for Biosensors, Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing University of Posts & Telecommunications, 9 Wenyuan Road, Nanjing 210023, China. Shaanxi Institute of Flexible Electronics (SIFE), Northwestern Polytechnical University (NPU), 127 West Youyi Road, Xi’an 710072, Shaanxi, China

Funding

Government of Jiangsu Province · National Natural Science Foundation of China · Priority Academic Program Development of Jiangsu Higher Education Institutions · Synergetic Innovation Center for Organic Electronics and Information Displays

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