journal article·2020-08-03

Making the Best Use of Excited-State Energy: Multimodality Theranostic Systems Based on Second Near-Infrared (NIR-II) Aggregation-Induced Emission Luminogens (AIEgens)

Wenhan Xu, Zhijun Zhang, Miaomiao Kang, Heng Guo, Youmei Li, Haifei Wen, Michelle M. S. Lee, Zhaoyu Wang, Ryan T. K. Kwok, Jacky W. Y. Lam, Kai Li, Lei Xi, Sijie Chen, Dong Wang, Ben Zhong Tang

ACS Materials Letters· Volume 2· Issue 8
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Abstract

A single-component multimodal theranostic platform that takes advantage of multiple imaging and therapy techniques may offer improved diagnostic monitoring capabilities and therapeutic efficacies. In this study, through structural tuning, a novel theranostic agent (TSSAM) with aggregation-induced emission (AIE) characteristics, bright second near-infrared (NIR-II) emission, high reactive oxygen species (ROS) generation capability, and excellent photothermal conversion efficiency (40.1%) was developed. TSSAM makes the best use of its excited-state energy and keeps perfect equilibrium between radiative and nonradiative transition to satisfy the needs of both NIR-II fluorescence imaging (FLI)/photoacoustic imaging (PAI)/photothermal imaging (PTI) trimodal imaging and photodynamic therapy (PDT)/photothermal therapy (PTT) synergistic therapy. Further experiments validated the superior imaging quality and tumoricidal activity of TSSAM, in which tumor tissues were completely eradicated and tumor metastasis was effectively inhibited by merely single injection and one-time laser irradiation. Therefore, this research presents a smart multifunctional material holding great promise in both basic research and clinical practice. Copyright © 2020 American Chemical Society.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Nanoplatforms for cancer theranostics · Luminescence and Fluorescent Materials · Photoacoustic and Ultrasonic Imaging

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Chemistry, The Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, Institute for Advanced Study, State Key Laboratory of Neuroscience, Division of Life Science and Department of Chemical and Biological Engineering, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong 999077, China

Center for AIE Research, Shenzhen Key Laboratory of Polymer Science and Technology, Guangdong Research Center for Interfacial Engineering of Functional Materials, College of Materials Science and Engineering, Shenzhen University, Shenzhen 518060, China

Department of Biomedical Engineering, SUSTech Academy for Advanced Interdisciplinary Studies, Southern University of Science and Technology (SUSTech), Shenzhen 518055, China

Ming Wai Lau Centre for Reparative Medicine, Karolinska Institutet, Sha Tin, Hong Kong

Funding

Research Grants Council, University Grants Committee · Innovation and Technology Commission · National Natural Science Foundation of China · Natural Science Foundation of Guangdong Province · Science and Technology Foundation of Shenzhen City · Ming Wai Lau Centre for Reparative Medicine, Karolinska Institutet

References (41)

Show source-provided references
1. 10.1002/bjs.581910.1002/bjs.5819 ↗
2. 10.1007/s10555-007-9056-010.1007/s10555-007-9056-0 ↗
3. 10.1038/nrc152910.1038/nrc1529 ↗
4. 10.1016/j.ctrv.2012.04.00710.1016/j.ctrv.2012.04.007 ↗
5. 10.1038/nrc204910.1038/nrc2049 ↗
6. 10.1038/nrc107110.1038/nrc1071 ↗
7. 10.1038/nrc189410.1038/nrc1894 ↗
8. 10.1021/ja057254a10.1021/ja057254a ↗
9. 10.1021/nl100996u10.1021/nl100996u ↗
10. 10.1038/nmeth82010.1038/nmeth820 ↗
11. 10.1126/science.108378010.1126/science.1083780 ↗
12. 10.1073/pnas.040687710210.1073/pnas.0406877102 ↗
13. 10.1038/nature0937810.1038/nature09378 ↗
14. Birks J. B. · 1970
15. 10.1021/acs.chemrev.5b0026310.1021/acs.chemrev.5b00263 ↗
16. 10.1002/adma.20140135610.1002/adma.201401356 ↗
17. 10.7150/thno.2778710.7150/thno.27787 ↗
18. 10.1002/smll.20160163710.1002/smll.201601637 ↗
19. 10.1016/j.chempr.2017.05.01010.1016/j.chempr.2017.05.010 ↗
20. 10.1002/adfm.20190812510.1002/adfm.201908125 ↗
21. 10.1038/s41467-020-15095-110.1038/s41467-020-15095-1 ↗
22. 10.1002/anie.20200589910.1002/anie.202005899 ↗
23. 10.1039/D0SC02911D10.1039/D0SC02911D ↗
24. 10.1016/j.nantod.2020.10089310.1016/j.nantod.2020.100893 ↗
25. 10.1038/nmat447610.1038/nmat4476 ↗
26. 10.1002/adfm.20190056610.1002/adfm.201900566 ↗
27. 10.7150/thno.2799510.7150/thno.27995 ↗
28. 10.1021/acs.accounts.8b0024210.1021/acs.accounts.8b00242 ↗
29. 10.1002/anie.20190956010.1002/anie.201909560 ↗
30. 10.1038/nbt.398710.1038/nbt.3987 ↗
31. 10.1021/jacs.8b1350710.1021/jacs.8b13507 ↗
32. 10.1038/nnano.2009.32610.1038/nnano.2009.326 ↗
33. 10.1002/adma.20190032110.1002/adma.201900321 ↗
34. 10.1002/anie.20200178310.1002/anie.202001783 ↗
35. 10.1002/anie.20190036610.1002/anie.201900366 ↗
36. 10.1002/adma.20180210510.1002/adma.201802105 ↗
37. 10.1021/jacs.8b1388910.1021/jacs.8b13889 ↗
38. 10.1021/acsami.0c0618110.1021/acsami.0c06181 ↗
39. 10.1002/anie.20200074010.1002/anie.202000740 ↗
40. 10.1021/acsnano.8b0313810.1021/acsnano.8b03138 ↗
41. 10.1021/jacs.9b0716210.1021/jacs.9b07162 ↗