Inhibition of Alzheimer amyloid β aggregation by polyvalent trehalose
Source abstract
Abstract
A glycopolymer carrying trehalose was found to suppress the formation of amyloid fibrils from the amyloid β peptide (1–42) (Aβ), as evaluated by thioflavin T assay and atomic force microscopy. Glycopolymers carrying sugar alcohols also changed the aggregation properties of Aβ, and the inhibitory effect depended on the type of sugar and alkyl side chain. Neutralization activity was confirmed by in vitro assay using HeLa cells. The glycopolymer carrying trehalose strongly inhibited amyloid formation and neutralized cytotoxicity.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Alzheimer's disease research and treatments · Cholinesterase and Neurodegenerative Diseases · Prion Diseases and Protein Misfolding
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
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