Sustained release of OIC-A006 from PLGA microspheres to induce osteogenesis of composite PLGA/β-TCP scaffolds
Source abstract
Abstract
Abstract In this article, poly(lactic- co -glycolic acid) (PLGA) microspheres containing the drug OIC-A006 were prepared by ice bath extraction and poly(lactic- co -glycolic acid)/ β-tricalcium phosphate (PLGA/β-TCP) scaffolds were prepared by freeze-drying. Three kinds of scaffold were prepared by adding no drug, direct loading the drug, and loading with drug microspheres. The mechanical strength, degradation, and microstructure of the scaffolds were analyzed. The drug delivery properties of the scaffolds were determined using high-performance liquid chromatography (HPLC). It was found that PLGA/β-TCP scaffolds with PLGA microspheres that contained the drug OIC-A006 exhibited a biphasic drug release pattern. Sustained release of the drug OIC-A006 was beneficial to cell adhesion and proliferation. Experiments on rats showed that composite PLGA/β-TCP scaffolds with PLGA microspheres containing the drug OIC-A006 produced good bone formation and bone induction.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Bone Tissue Engineering Materials · biodegradable polymer synthesis and properties · Graphene and Nanomaterials Applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Rapid Manufacture Engineering Center, School of Mechatronic Engineering and Automation , Shanghai University , 99 Shangda Road, BaoShan District , Shanghai 200444 , China
Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital , Shanghai Jiao Tong University School of Medicine , 197 Rui Jin 2nd Road , Shanghai 200025 , China
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