Microemulsion synthesis of zinc-containing mesoporous bioactive silicate glass nanoparticles: In vitro bioactivity and drug release studies
Source abstract
Abstract
Abstract Mesoporous materials have recently garnered significant interest in biomedical applications. This work successfully synthesized mesoporous silica nanoparticles (MSNs) and bioactive glass nanoparticles (MBGs) containing (75 − X )% SiO 2 –5% P 2 O 5 –20% CaO– X % ZnO ( X = 0, 2.5, and 5 wt%) using a microemulsion technique. Then, MBGs and MSNs were compared using different characterization methods and in vitro bioactivity assays. The release kinetics and drug release mechanism of the prepared samples were evaluated using dexamethasone (DEX) as a model drug. The transmission electron microscope and Brunauer–Emmet–Teller method showed that MSNs exhibited spherical shapes with no agglomeration, a surface area of 381 m 2 ·g −1 , and an average particle size of about 15 nm. However, MBG particles with 5% Zn were nearly agglomerated, spherical with a 280 m 2 ·g −1 surface area and 64 nm particle size. In vitro bioactivity results showed that MBG was more bioactive than MSN due to the addition of ions that enhanced biomineralization and thus bioactivity. MSN samples released DEX faster than MBG samples, making them suitable for high-dose, short-duration cases. However, the cumulative DEX release from S4 was acceptable for long-term high-release cases. These results show that regulating the concentrations of therapeutic ions can effectively regulate the drug’s release kinetics, protein adsorption, and enhance bioactivity.
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Research context
OpenAlex topics: Bone Tissue Engineering Materials · Pigment Synthesis and Properties · Catalysis and Oxidation Reactions
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Physics Department, Faculty of Science, King Abdulaziz University , Jeddah , Saudi Arabia
Physics Department, Faculty of Science, Al-Azhar University , Nasr City , Cairo , Egypt
Biophysics Branch, Physics Department, Faculty of Science, Al-Azhar University , Nasr City , 11884, Cairo , Egypt
References (66)
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