Magnetic Sio2-Fe3O4 Nanocomposites as Carriers of Ibuprofen for Controlled Release Applications
Source abstract
Abstract
Abstract In the present paper, we report the preparation and characterization of magnetic silica nanostructured materials that were used as ibuprofen drug molecule carriers. This work was aimed at obtaining drug release systems sensitive to a magnetic field to be directed to target sites. The preparation of the silica nanostructuredmaterials started with the synthesis of magnetite (Fe3O4) nanoparticles that were added subsequently during the hydrolysis and condensation of tetraethyl-orthosilicate (TEOS) to obtain SiO2-Fe3O4 nanocomposites. The ibuprofen molecules were added simultaneously with magnetite nanoparticles. The in vitro ibuprofen release profiles were analyzed, showing a typical controlled release for all materials studied. The nanocomposites were characterized by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), scanning microscopy (SEM), thermogravimetric analysis (TGA), N2 adsorption-desorption isotherms; magnetic studies were also performed. The obtained materials showed low superparamagnetic values, and saturation behavior was also observed. It was demonstrated that ibuprofen does not affect the magnetic behavior of magnetite, indicating its possible use in medical applications.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Nanoparticle-Based Drug Delivery · Advanced Drug Delivery Systems · Nanomaterials for catalytic reactions
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Institute of Materials Science and Technology, Polymer Laboratory,University of Havana,10400 Havana City, Cuba
Center for Research in Applied Science and Advanced Technology, IPN, Legaría 694, 11500 México City, México
Institute of Physics of Nice, University Côte d’Azur, Parc Valrose, Nice 06100, France
Laboratory of Polymer Blends and Composites Macromolecules Conductors, Institute of the Federal University of Rio de Janeiro,Av. Pedro Calmon 550, 21941-901 Rio de Janeiro , Brazil
Department of Physical Chemistry, Faculty of Chemistry, University of Havana, 10600 Havana City, Cuba
Nanotechnology Laboratory, National Institute of Neurology and Neurosurgery, Insurgentes Sur 3877, La Fama, 14269 México City , México
References (40)
Show source-provided references
1. [1] E. Blanco, H. Shen and M. Ferrari // Nat. Biotechnol. 33 (2015) 941.10.1038/nbt.333049785092634896510.1038/nbt.3330 ↗
2. [2] R. Fernandes and D.H. Gracias // Adv. Drug. Deliv. Rev. 64 (2012) 1579.10.1016/j.addr.2012.02.01234628972242561210.1016/j.addr.2012.02.012 ↗
3. [3] V. Sharma, S. Anandhakumar and M. Sasidharan // Mater. Sci. Eng. C Mater. Biol. Appl. 56 (2015) 393.10.1016/j.msec.2015.06.0492624960610.1016/j.msec.2015.06.049 ↗
4. [4] U. Wais, A.W. Jackson, T. He and H. Zhang // Nanoscale 8 (2015) 1746.10.1039/C5NR07161E10.1039/C5NR07161E ↗
5. [5] X.J. Cai and Y.Y. Xu // Cytotechnology 63 (2011) 319.10.1007/s10616-011-9366-531408422172079610.1007/s10616-011-9366-5 ↗
6. [6] N. Habibi, N. Kamaly, A. Memic and H. Shafiee // Nano. Today 11 (2016) 41.10.1016/j.nantod.2016.02.00448349072710393910.1016/j.nantod.2016.02.004 ↗
7. [7] M. Palombo, M. Deshmukh, D. Myers, J. Gao, Z. Szekely and P.J. Sinko // Annu. Rev Pharmacol. Toxicol. 54 (2014) 581.10.1146/annurev-pharmtox-010611-13461542071232416069510.1146/annurev-pharmtox-010611-134615 ↗
8. [8] C. Iancu, I.R. Ilie, C.E. Georgescu, R. Ilie, A.R. Biris, T. Mocan, L.C. Mocan, F. Zaharie, D. Todea-Iancu, S. Susman, D. Ciuca and A.S. Biris // Partcul. Sci. Technol. 27 (2009) 5624.10.1080/0272635090332898510.1080/02726350903328985 ↗
9. [9] M. Malmsten // Curr. Opin. Colloid. Int. 18 (2013) 468.10.1016/j.cocis.2013.06.00210.1016/j.cocis.2013.06.002 ↗
10. [10] R. Jayakumar, D. Menon, K. Manzoor, S.V. Nair and H. Tamura // Carbohydr. Polym. 82 (2010) 227.10.1016/j.carbpol.2010.04.07410.1016/j.carbpol.2010.04.074 ↗
11. [11] N. Kameta // J. Incl. Phenom. Macrocycl. Chem. 79 (2014) 1.10.1007/s10847-014-0397-310.1007/s10847-014-0397-3 ↗
12. [12] C. Sanchez, P. Belleville, M. Popalld and L. Nicole // Chem. Soc. Rev. 40 (2011) 696.10.1039/c0cs00136h10.1039/c0cs00136h ↗
13. [13] M. Karimi, P.S. Zangabad, A. Ghasemi and M.R. Hamblin, In: Smart External Stimulus- Responsive Nanocarriers for Drug andGene Delivery, ed. byMorgan &Claypool Publishers (2015).10.1088/978-1-68174-202-1ch510.1088/978-1-6817-4202-1 ↗
14. [14] M. Nakayama, T. Okano, T. Miyazaki, F. Kohori, K. Sakai and M. Yokoyama // J. Control. Release. 115 (2006) 46.10.1016/j.jconrel.2006.07.0071692021710.1016/j.jconrel.2006.07.007 ↗
15. [15] H. Shagholani, S.M. Ghoreishi and M. Mousazadeh // ýInt. J. Biol. Macromolec. 78 (2015) 130.10.1016/j.ijbiomac.2015.02.04210.1016/j.ijbiomac.2015.02.042 ↗
16. [16] K.S. Soppimath, T.M. Aminabhavi, A.M. Dave, S.G. Kumbar and W.E. Rudzinski // Drug. Dev. Ind. Pharm. 28 (2002) 957.10.1081/DDC-1200064281237896510.1081/DDC-120006428 ↗
17. [17] S. Guo, D. Li, L. Zhang, J. Li and E. Wang// Biomaterials 30 (2009) 1881.10.1016/j.biomaterials.2008.12.0421913524810.1016/j.biomaterials.2008.12.042 ↗
18. [18] C.W. Zhang, C.C. Zeng and Y. Xu // NANO: Brief Reports and Reviews 9 (2014) 1.
19. [19] M. Ahmed and M. Douek // Bio. Med. Research. International 2013 (2013) 1.10.1155/2013/28123037229072393678410.1155/2013/281230 ↗
20. [20] J. Xu, F. Zhang, J. Sun, J. Sheng, F. Wang and M. Sun // Molecules 19 (2014) 21506.10.3390/molecules19122150610.3390/molecules191221506 ↗
21. [21] F. Chen, L. Zhang, Q. Chen, Y. Zhang and Z. Zhang // Chem. Commun. 46 (2010) 8633.10.1039/c0cc02577a10.1039/c0cc02577a ↗
22. [22] E.V. Escobar, C.A. Martínez, C.A. Rodríguez, J.S. Castro, M.A. Quevedo and P.E. García-Casillas // J. Alloys. Compd. 536S (2012) S441.10.1016/j.jallcom.2011.12.15010.1016/j.jallcom.2011.12.150 ↗
23. [23] S. Abramson, W. Safraou, B. Malezieux, V. Dupuis, S. Borensztajn, E. Briot and A. Bée // J. Colloid. Interface. Sci. 364 (2011) 324.10.1016/j.jcis.2011.08.0562192567110.1016/j.jcis.2011.08.056 ↗
24. [24] T. Liu, L. Liu, J. Liu, S. Liu and S.Z. Qiao // Front. Chem. Sci. Eng. 8 (2014) 114.10.1007/s11705-014-1413-210.1007/s11705-014-1413-2 ↗
25. [25] K. Viswanathan // Colloids and Surfaces A: Physicochem. Eng. Aspects. 386 (2011) 11.10.1016/j.colsurfa.2011.06.01710.1016/j.colsurfa.2011.06.017 ↗
26. [26] B. Chang, J. Guo, C. Liu, J. Qian and W. Yang // J. Mater. Chem. 20 (2010) 9941.10.1039/c0jm01237h10.1039/c0jm01237h ↗
27. [27] S. Hu, T. Liu, H. Huang, D. Liu and S. Chen // Langmuir 24 (2008) 239.10.1021/la701570z10.1021/la701570z ↗
28. [28] J.E. Lee, N. Lee, H. Kim, J. Kim, S.H. Choi, J.H. Kim, T. Kim, I.C. Song, S.P. Park, W.K. Moon and T. Hyeon // J. Am. Chem. Soc. 132 (2010) 55210.1021/ja905793q
29. [29] K.C. Souza, J.D. Ardisson and E.M.B. Sousa // J. Mater. Sci: Mater. Med. 20 (2009) 507.10.1007/s10856-008-3592-11883928310.1007/s10856-008-3592-1 ↗
30. [30] C. Tao and Y. Zhu // Dalton. Trans. 43 (2014) 15482.10.1039/C4DT01984A10.1039/C4DT01984A ↗
31. [31] J. Hwang, E. Lee, J. Kim, Y. Seo, K.H. Lee, J.W. Hong, A.A. Gilad, H. Park and J. Choi // Colloids Sur. B 142 (2016) 290.10.1016/j.colsurfb.2016.01.04010.1016/j.colsurfb.2016.01.040 ↗
32. [32] O. Mykhaylyk, T. Sobisch, I. Almstätter, Y. Sanchez-Antequera, S. Brandt, M. Anton, M. Döblinger, D. Eberbeck, M. Settles, R. Braren, D. Lerche and C. Plank // Pharm. Res. 29 (2012) 1344.10.1007/s11095-011-0661-910.1007/s11095-011-0661-9 ↗
33. [33] G. Yang, H. Gong, T. Liu, X. Sun, L. Cheng and Z. Liu // Biomaterials 60 (2015) 62.10.1016/j.biomaterials.2015.04.05310.1016/j.biomaterials.2015.04.053 ↗
34. [34] Y. Zhou, Y. Zeng, S. Huang, Q. Xie, Y. Fu, L. Tan, M. Ma and S. Yao // Sens. Actuators, B 173 (2012) 433.10.1016/j.snb.2012.07.06310.1016/j.snb.2012.07.063 ↗
35. [35] S. Qu, H. Yang, D. Ren, S. Kan, G. Zou, D. Li and M. Li // J. Colloid. Interface. Sci. 215 (1999) 190.10.1006/jcis.1999.61851036248910.1006/jcis.1999.6185 ↗
36. [36] M. Khalkhali, K. Rostamizadeh, S. Sadighian, F. Khoeini and M. Naghibi // Materials 6 (2013) 184.
37. [37] M. Abboud, S. Youssef, J. Podlecki, R. Habchi, G. Germanos and A. Foucaran // Mater. Sci. Semicond. Process 39 (2015) 641.10.1016/j.mssp.2015.05.03510.1016/j.mssp.2015.05.035 ↗
38. [38] M. Khalkhali, K. Rostamizadeh, S. Sadighian, F. Khoeini, M. Naghibi and M. Hamidi // J Pharm. Sci. 23 (2015) 45.10.1186/s40199-015-0124-710.1186/s40199-015-0124-7 ↗
39. [39] T. Neuberger, B. Schöpf, H. Hofmann, M. Hofmann and B. von Rechenberg // J. Magn.Magn.Mater. 293 (2005) 483.10.1016/j.jmmm.2005.01.06410.1016/j.jmmm.2005.01.064 ↗
40. [40] M.H. Shoaib, J. Tazeen, H.A. Merchant and R.I. Yousuf // Pak. J. Pharm. Sci. 19 (2006) 119.