journal article·2023-05-29Open access

Hemp seed oil nanoemulsion with Sapindus saponins as a potential carrier for iron supplement and vitamin D

Wojciech Smułek, Maciej Jarzębski

Abstract

Abstract Vitamin D3 and iron are important components of a balanced diet. Supplementing meals with these is essential to support the recovery of humankind’s malnutrition. It is necessary to develop effective delivery systems to ensure the high bioavailability of these hydrophobic components. For this purpose, emulsions were prepared based on hemp seed oil and with soap nut extract (Sapindus mukorossi fruits) as a natural emulsifier. To characterize the differences in the properties of the emulsions depending on the content of the oil phase and the emulsifier, measurements were performed to determine the following parameters: the color characteristics, transparency of the samples, infrared spectrum, particle size distribution, polydispersity of the system, and the rheological properties of the emulsions. The results showed that the highest stability was observed in systems with a relatively low oil concentration, i.e., 1%. These samples also had an average particle size not exceeding 200 nm. In turn, the low oil content significantly reduced the dynamic viscosity of the emulsions. At the same time, microscopic observations indicated that the presence of an oil phase was advantageous, not only because of the possibility of providing vitamin D but also because of the high hydrophobicity of the iron particles. Therefore, the realized research made it possible to identify the optimal emulsion composition. The created system can find applications in delivering dietary supplements such as vitamin D3 and iron by providing high dispersion of components and high stability.
Source: crossref · Quality: baseline

Research context

OpenAlex topics: Polysaccharides Composition and Applications · Proteins in Food Systems · Hibiscus Plant Research Studies

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Institute of Chemical Technology and Engineering, Poznan University of Technology , 4 Berdychowo Str., 60-965 Poznań , Poland

Department of Physics and Biophysics, Poznań University of Life Sciences , 38/42 Wojska Polskiego Str., 60-637 Poznań , Poland

References (41)

Show source-provided references
1. Rein, M. J., M. Renouf, C. Cruz-Hernandez, L. Actis-Goretta, S. K. Thakkar, and M. da Silva Pinto. Bioavailability of bioactive food compounds: A challenging journey to bioefficacy: Bioavailability of bioactive food compounds. British Journal of Clinical Pharmacology, Vol. 75, No. 3, 2013 Mar, pp. 588–602.10.1111/j.1365-2125.2012.04425.x ↗
2. Neilson, A. P., K. M. Goodrich, and M. G. Ferruzzi. Bioavailability and metabolism of bioactive compounds from foods. Nutrition in the prevention and treatment of disease [Internet], Elsevier, Amsterdam, 2017, pp. 301–319. [cited 2023 Mar 27]. https://linkinghub.elsevier.com/retrieve/pii/B9780128029282000151.10.1016/B978-0-12-802928-2.00015-1 ↗
3. Smułek, W. and E. Kaczorek. Factors influencing the bioavailability of organic molecules to bacterial cells—A mini-review. Molecules, Vol. 27, No. 19, 2022 Oct 4, id. 6579.10.3390/molecules27196579 ↗
4. Marek, K., N. Cichoń, J. Saluk-Bijak, M. Bijak, and E. Miller. The role of vitamin D in stroke prevention and the effects of its supplementation for post-stroke rehabilitation: A narrative review. Nutrients, Vol. 14, No. 13, 2022 Jul 4, id. 2761.10.3390/nu14132761 ↗
5. Teymoori-Rad, M., F. Shokri, V. Salimi, and S. M. Marashi. The interplay between vitamin D and viral infections. Reviews in Medical Virology, Vol. 29, No. 2, 2019 Mar, id. e2032.10.1002/rmv.2032 ↗
6. Taha, R., S. Abureesh, S. Alghamdi, R. Y. Hassan, M. M. Cheikh, R. A. Bagabir, et al. The relationship between vitamin D and infections including COVID-19: Any hopes? International Journal of General Medicine, Vol. 14, 2021 Jul, pp. 3849–3870.10.2147/IJGM.S317421 ↗
7. Šimoliūnas, E., I. Rinkūnaitė, Ž. Bukelskienė, and V. Bukelskienė. Bioavailability of different vitamin D oral supplements in laboratory animal model. Medicina, Vol. 55, No. 6, 2019 Jun 10, id. 265.10.3390/medicina55060265 ↗
8. Zielińska-Dawidziak, M. Plant ferritin—A source of iron to prevent its deficiency. Nutrients, Vol. 7, No. 2, 2015 Feb 12, pp. 1184–1201.10.3390/nu7021184 ↗
9. Zielińska-Dawidziak, M., I. Hertig, H. Staniek, D. Piasecka-Kwiatkowska, and K. W. Nowak. Effect of iron status in rats on the absorption of metal ions from plant ferritin. Plant Foods for Human Nutrition, Vol. 69, No. 2, 2014 Jun, pp. 101–107.10.1007/s11130-014-0413-1 ↗
10. Kangas, S. T., C. Salpéteur, V. Nikièma, L. Talley, A. Briend, C. Ritz, et al. Vitamin A and iron status of children before and after treatment of uncomplicated severe acute malnutrition. Clinical Nutrition, Vol. 39, No. 11, 2020 Nov, pp. 3512–3519.10.1016/j.clnu.2020.03.016 ↗
11. Stoffel, N. U., H. K. von Siebenthal, D. Moretti, and M. B. Zimmermann. Oral iron supplementation in iron-deficient women: How much and how often? Molecular Aspects of Medicine, Vol. 75, 2020 Oct, id. 100865.10.1016/j.mam.2020.100865 ↗
12. Merker, M., A. Amsler, R. Pereira, R. Bolliger, P. Tribolet, N. Braun, et al. Vitamin D deficiency is highly prevalent in malnourished inpatients and associated with higher mortality: A prospective cohort study. Medicine, Vol. 98, No. 48, 2019 Nov, id. e18113.10.1097/MD.0000000000018113 ↗
13. Jarzębski, M., P. Siejak, W. Smułek, F. Fathordoobady, Y. Guo, J. Pawlicz, et al. Plant extracts containing saponins affects the stability and biological activity of hempseed oil emulsion system. Molecules, Vol. 25, No. 11, 2020 Jun 10, id. 2696.10.3390/molecules25112696 ↗
14. Martel-Estrada, S. A., A. I. Morales-Cardona, C. L. Vargas-Requena, J. A. Rubio-Lara, C. A. Martínez-Pérez, and F. Jimenez-Vega. Delivery systems in nanocosmeceuticals. Reviews on Advanced Materials Science, Vol. 61, No. 1, 2022 Dec 27, pp. 901–930.10.1515/rams-2022-0282 ↗
15. Abdellatif, A. A. H., H. A. Mohammed, R. A. Khan, V. Singh, A. Bouazzaoui, M. Yusuf, et al. Nano-scale delivery: A comprehensive review of nano-structured devices, preparative techniques, site-specificity designs, biomedical applications, commercial products, and references to safety, cellular uptake, and organ toxicity. Nanotechnology Reviews, Vol. 10, No. 1, 2021 Oct 21, pp. 1493–1559.10.1515/ntrev-2021-0096 ↗
16. Javed, S., B. Mangla, Y. Almoshari, M. H. Sultan, and W. Ahsan. Nanostructured lipid carrier system: A compendium of their formulation development approaches, optimization strategies by quality by design, and recent applications in drug delivery. Nanotechnology Reviews, Vol. 11, No. 1, 2022 Apr 22, pp. 1744–1777.10.1515/ntrev-2022-0109 ↗
17. Maamoun, W., M. I. Badawi, A. A. Aly, and Y. Khedr. Nanoparticles in enhancing microwave imaging and microwave Hyperthermia effect for liver cancer treatment. Reviews on Advanced Materials Science, Vol. 60, No. 1, 2021 Jan 1, pp. 223–236.10.1515/rams-2021-0014 ↗
18. Vodolazska, D. and C. Lauridsen. Effects of dietary hemp seed oil to sows on fatty acid profiles, nutritional and immune status of piglets. Journal of Animal Science and Biotechnology, Vol. 11, No. 1, 2020 Dec, id. 28.10.1186/s40104-020-0429-3 ↗
19. Góral, I. and K. Wojciechowski. Surface activity and foaming properties of saponin-rich plants extracts. Advances in Colloid and Interface Science, Vol. 279, 2020 May, id. 102145.10.1016/j.cis.2020.102145 ↗
20. Mondal, M. H., S. Malik, A. Garain, S. Mandal, and B. Saha. Extraction of natural surfactant saponin from soapnut (Sapindus mukorossi) and its utilization in the remediation of hexavalent chromium from contaminated water. Tenside, Surfactants, Detergents, Vol. 54, No. 6, 2017 Nov 15, pp. 519–529.10.3139/113.110523 ↗
21. Kozińska, N., K. Tokarska, M. Chudy, and K. Wojciechowski. Cytotoxicity of quillaja saponaria saponins towards lung cells is higher for cholesterol-rich cells. Biophysica, Vol. 1, No. 2, 2021 Apr 6, pp. 126–136.10.3390/biophysica1020010 ↗
22. EFSA Panel on Food Additives and Flavourings (FAF), M. Younes, G. Aquilina, L. Castle, K. Engel, P. Fowler, et al. Re‐evaluation of Quillaia extract (E 999) as a food additive and safety of the proposed extension of use. EFS2 [Internet], Vol. 17, No. 3, 2019 Mar. [cited 2023 Mar 27] https://data.europa.eu/doi/10.2903/j.efsa.2019.5622.10.2903/j.efsa.2019.5622 ↗
23. Chen, C., R. Li, D. Li, F. Shen, G. Xiao, and J. Zhou. Extraction and purification of saponins from Sapindus mukorossi. New Journal of Chemistry, Vol. 45, No. 2, 2021, pp. 952–960.10.1039/D0NJ04047A ↗
24. Smułek, W., A. Zdarta, M. Łuczak, P. Krawczyk, T. Jesionowski, and E. Kaczorek. Sapindus saponins’ impact on hydrocarbon biodegradation by bacteria strains after short- and long-term contact with pollutant. Colloids and Surfaces B: Biointerfaces, Vol. 142, 2016 Jun, pp. 207–213.10.1016/j.colsurfb.2016.02.049 ↗
25. Pratap-Singh, A., Y. Guo, S. Lara Ochoa, F. Fathordoobady, and A. Singh. Optimal ultrasonication process time remains constant for a specific nanoemulsion size reduction system. Scientific Reports, Vol. 11, No. 1, 2021 Apr 29, id. 9241.10.1038/s41598-021-87642-9 ↗
26. Fathordoobady, F., N. Sannikova, Y. Guo, A. Singh, D. D. Kitts, and A. Pratap-Singh. Comparing microfluidics and ultrasonication as formulation methods for developing hempseed oil nanoemulsions for oral delivery applications. Scientific Reports, Vol. 11, No. 1, 2021 Jan 8, id. 72.10.1038/s41598-020-79161-w ↗
27. Jarzębski, M., W. Smułek, P. Siejak, R. Rezler, J. Pawlicz, T. Trzeciak, et al. Aesculus hippocastanum L. as a stabilizer in hemp seed oil nanoemulsions for potential biomedical and food applications. International Journal of Molecular Sciences, Vol. 22, No. 2, 2021 Jan 17, id. 887.10.3390/ijms22020887 ↗
28. Grzechulska-Damszel, J., A. Markowska-Szczupak, G. Zolnierkiewicz, J. Typek, N. Guskos, and A. W. Morawski. On the characteristic and stability of iron diet supplements. Polish Journal of Chemical Technology, Vol. 21, No. 3, 2019 Sep 1, pp. 60–67.10.2478/pjct-2019-0031 ↗
29. Sahu, D., D. Bharti, D. Kim, P. Sarkar, and K. Pal. Variations in microstructural and physicochemical properties of candelilla wax/rice bran oil–derived oleogels using sunflower lecithin and soya lecithin. Gels, Vol. 7, No. 4, 2021 Nov 22, id. 226.10.3390/gels7040226 ↗
30. Chung, C., A. Sher, P. Rousset, and D. J. McClements. Use of natural emulsifiers in model coffee creamers: Physical properties of Quillaja saponin-stabilized emulsions. Food Hydrocolloids, Vol. 67, 2017 Jun, pp. 111–119.10.1016/j.foodhyd.2017.01.008 ↗
31. Chung, C., A. Sher, P. Rousset, E. A. Decker, and D. J. McClements. Formulation of food emulsions using natural emulsifiers: Utilization of Quillaja saponin and soy lecithin to fabricate liquid coffee whiteners. Journal of Food Engineering, Vol. 209, 2017 Sep, pp. 1–11.10.1016/j.jfoodeng.2017.04.011 ↗
32. Jarzębski, M., B. Bellich, T. Białopiotrowicz, T. Śliwa, J. Kościński, and A. Cesàro. Particle tracking analysis in food and hydrocolloids investigations. Food Hydrocolloids, Vol. 68, 2017 Jul, pp. 90–101.10.1016/j.foodhyd.2016.09.037 ↗
33. Schreiner, T. B., M. M. Dias, M. F. Barreiro, and S. P. Pinho. Saponins as natural emulsifiers for nanoemulsions. Journal of Agricultural and Food Chemistry, Vol. 70, No. 22, 2022 Jun 8, pp. 6573–6590.10.1021/acs.jafc.1c07893 ↗
34. Yang, Y., M. E. Leser, A. A. Sher, and D. J. McClements. Formation and stability of emulsions using a natural small molecule surfactant: Quillaja saponin (Q-Naturale®). Food Hydrocolloids, Vol. 30, No. 2, 2013 Mar, pp. 589–596.10.1016/j.foodhyd.2012.08.008 ↗
35. Sotomayor-Gerding, D., E. Morales, and M. Rubilar. Comparison between quinoa and quillaja saponins in the formation, stability and digestibility of astaxanthin-canola oil emulsions. Colloids and Interfaces, Vol. 6, No. 3, 2022 Aug 28, id. 43.10.3390/colloids6030043 ↗
36. Gundewadi, G., D. J. Sarkar, S. G. Rudra, and D. Singh. Preparation of basil oil nanoemulsion using Sapindus mukorossi pericarp extract: Physico-chemical properties and antifungal activity against food spoilage pathogens. Industrial Crops and Products, Vol. 125, 2018 Dec, pp. 95–104.10.1016/j.indcrop.2018.08.076 ↗
37. Tsibranska, S., S. Tcholakova, K. Golemanov, N. Denkov, E. Pelan, and S. D. Stoyanov. Role of interfacial elasticity for the rheological properties of saponin-stabilized emulsions. Journal of Colloid and Interface Science, Vol. 564, 2020 Mar, pp. 264–275.10.1016/j.jcis.2019.12.108 ↗
38. Rezler, R. The role of starch in shaping the rheo-mechanical properties of fat-in-water emulsions. Polysaccharides, Vol. 3, No. 4, 2022 Dec 5, pp. 804–817.10.3390/polysaccharides3040047 ↗
39. Fu, L., Q. Ma, K. Liao, J. An, J. Bai, and Y. He. Application of pickering emulsion in oil drilling and production. Nanotechnology Reviews, Vol. 11, No. 1, 2021 Dec 3, pp. 26–39.10.1515/ntrev-2022-0003 ↗
40. Wong, S. K., L. E. Low, J. Supramaniam, S. Manickam, T. W. Wong, C. H. Pang, et al. Physical stability and rheological behavior of Pickering emulsions stabilized by protein–polysaccharide hybrid nanoconjugates. Nanotechnology Reviews, Vol. 10, No. 1, 2021 Sep 27, pp. 1293–1305.10.1515/ntrev-2021-0090 ↗
41. Li, Z., L. Dai, D. Wang, L. Mao, and Y. Gao. Stabilization and rheology of concentrated emulsions using the natural emulsifiers quillaja saponins and rhamnolipids. Journal of Agricultural and Food Chemistry, Vol. 66, No. 15, 2018 Apr 18, pp. 3922–3929.10.1021/acs.jafc.7b05291 ↗