journal article·2023-03-10Open access

Application prospect of calcium peroxide nanoparticles in biomedical field

Xincai Wu, Xu Han, Yang Guo, Qian Liu, Ran Sun, Zhaohui Wen, Changsong Dai

Abstract

Abstract In recent years, calcium peroxide (CaO2) has attracted widespread attention in the medical community due to its excellent antitumor and antibacterial properties, and has gradually become a hot research topic in the biomedical field. CaO2 reacts with water (H2O) to produce calcium ion (Ca2+), oxygen (O2), and hydrogen peroxide (H2O2), where Ca2+ is suitable for calcium death caused by calcium overload, O2 is suitable for O2-dependent anticancer therapy, and H2O2 is suitable for H2O2-dependent anticancer therapy. In addition, H2O2 can also be used in the antibacterial field to treat bacterial infections. All these make the CaO2 to become a kind of excellent antitumor and antibacterial drug. This study mainly reviews the preparation and surface modification of CaO2, probes into the latest progress about CaO2 nanoparticles in the field of tumor treatment and antimicrobial therapy. Finally, the challenges that CaO2 still faces in the future research field are clarified, and its prospects are forecasted.
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Research context

OpenAlex topics: Nanoplatforms for cancer theranostics · Advanced Nanomaterials in Catalysis · Nanoparticle-Based Drug Delivery

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Neuro Intern, First Affiliated Hospital of Harbin Medical University , Harbin 150001 , China

School of Chemistry and Chemical Engineering, Harbin Institute of Technology , Harbin 150001 , China

References (100+)

Show source-provided references
1. Lin, L., S. Wang, H. Deng, W. Yang, L. Rao, R. Tian, et al. Endogenous labile iron pool-mediated free radical generation for cancer chemodynamic therapy. Journal of the American Chemical Society, Vol. 142, No. 36, 2020, pp. 15320–15330.10.1021/jacs.0c05604 ↗
2. Gao, F., M. Sun, J. Zhang, Y. Chang, W. Gao, G. Ma, et al. Fenton-like reaction and glutathione depletion by chiral manganese dioxide nanoparticles for enhanced chemodynamic therapy and chemotherapy. Journal of Colloid and Interface Science, Vol. 616, 2022, pp. 369–378.10.1016/j.jcis.2022.02.060 ↗
3. Wan, Y., L. H. Fu, C. Li, J. Lin, and P. Huang. Conquering the hypoxia limitation for photodynamic therapy. Advanced Materials, Vol. 33, No. 48, 2021, id. 2103978.10.1002/adma.202103978 ↗
4. Zhao, X., J. Liu, J. Fan, H. Chao, and X. Peng. Recent progress in photosensitizers for overcoming the challenges of photodynamic therapy: from molecular design to application. Chemical Society Reviews, Vol. 50, No. 6, 2021, pp. 4185–4219.10.1039/D0CS00173B ↗
5. Duosiken, D., R. Yang, Y. Dai, Z. Marfavi, Q. Lv, H. Li, et al. Near-infrared light-excited reactive oxygen species generation by thulium oxide nanoparticles. Journal of the American Chemical Society, Vol. 144, No. 6, 2022, pp. 2455–2459.10.1021/jacs.1c11704 ↗
6. Ding, L., Y. Chang, P. Yang, W. Gao, M. Sun, Y. Bie, et al. Facile synthesis of biocompatible l-cysteine-modified MoS2 nanospheres with high photothermal conversion efficiency for photothermal therapy of tumor. Materials Science and Engineering: C, Vol. 117, 2020, id. 111371.10.1016/j.msec.2020.111371 ↗
7. Xie, L., M. Yan, T. Liu, K. Gong, X. Luo, B. Qiu, et al. Kinetics-controlled super-assembly of asymmetric porous and hollow carbon nanoparticles as light-sensitive smart nanovehicles. Journal of the American Chemical Society, Vol. 144, No. 4, 2022, pp. 1634–1646.10.1021/jacs.1c10391 ↗
8. Li, G., S. Wang, D. Deng, Z. Xiao, Z. Dong, Z. Wang, et al. Fluorinated chitosan to enhance transmucosal delivery of sonosensitizer-conjugated catalase for sonodynamic bladder cancer treatment post-intravesical instillation. ACS Nano, Vol. 14, No. 2, 2020, pp. 1586–1599.10.1021/acsnano.9b06689 ↗
9. Kong, H., Q. Chu, C. Fang, G. Cao, G. Han, and X. Li. Cu–ferrocene‐functionalized CaO2 nanoparticles to enable tumor‐specific synergistic therapy with GSH depletion and calcium overload. Advanced Science, Vol. 8, No. 14, 2021, id. 2100241.10.1002/advs.202100241 ↗
10. Qiao, Y., Y. Xu, X. Liu, Y. Zheng, B. Li, Y. Han, et al. Microwave assisted antibacterial action of Garcinia nanoparticles on Gram-negative bacteria. Nature Communications, Vol. 13, No. 1, 2022, pp. 1–13.10.1038/s41467-022-30125-w ↗
11. Willyard, C. Drug-resistant bacteria ranked. Nature, Vol. 543, No. 7643, 2017, id. 15.10.1038/nature.2017.21550 ↗
12. Li, X., S. M. Robinson, A. Gupta, K. Saha, Z. Jiang, D. F. Moyano, et al. Functional gold nanoparticles as potent antimicrobial agents against multi-drug-resistant bacteria. ACS Nano, Vol. 8, No. 10, 2014, pp. 10682–10686.10.1021/nn5042625 ↗
13. Northup, A. and D. Cassidy. Calcium peroxide (CaO2) for use in modified Fenton chemistry. Journal of Hazardous Materials, Vol. 152, No. 3, 2008, pp. 1164–1170.10.1016/j.jhazmat.2007.07.096 ↗
14. Northup, A. M. Modified fenton oxidation of hydrocarbon contaminated soils with CaO2: Microbial survival and surfactant production, 2007. Dissertations. 3507.
15. Zhang, M., R. Song, Y. Liu, Z. Yi, X. Meng, J. Zhang, et al. Calcium-overload-mediated tumor therapy by calcium peroxide nanoparticles. Chem, Vol. 5, No. 8, 2019, pp. 2171–2182.10.1016/j.chempr.2019.06.003 ↗
16. Ma, Y., H. Xu, B. Sun, S. Du, S. Cui, L. Zhang, et al. pH-responsive oxygen and hydrogen peroxide self-supplying nanosystem for photodynamic and chemodynamic therapy of wound infection. ACS Applied Materials & Interfaces, Vol. 13, No. 50, 2021, pp. 59720–59730.10.1021/acsami.1c19681 ↗
17. Liu, J., Y. Jin, Z. Song, L. Xu, Y. Yang, X. Zhao, et al. Boosting tumor treatment by dredging the hurdles of chemodynamic therapy synergistic ion therapy. Chemical Engineering Journal, Vol. 411, 2021, id. 128440.10.1016/j.cej.2021.128440 ↗
18. He, Y., K. Li, X. Yang, J. Leng, K. Xu, Z. Yuan, et al. Calcium peroxide nanoparticles‐embedded coatings on anti‐inflammatory TiO2 nanotubes for bacteria elimination and inflammatory environment amelioration. Small, Vol. 17, No. 47, 2021, id. 2102907.10.1002/smll.202102907 ↗
19. Wang, X., C. Li, H. Jin, X. Wang, C. Ding, D. Cao, et al. Mutual promotion of oxidative stress amplification and calcium overload by degradable spatially selective self-cascade catalyst for synergistic tumor therapy. Chemical Engineering Journal, Vol. 432, 2022, id. 134438.10.1016/j.cej.2021.134438 ↗
20. He, J., L.-H. Fu, C. Qi, J. Lin, and P. Huang. Metal peroxides for cancer treatment. Bioactive Materials, Vol. 6, No. 9, 2021, pp. 2698–2710.10.1016/j.bioactmat.2021.01.026 ↗
21. Khodaveisi, J., H. Banejad, A. Afkhami, E. Olyaie, S. Lashgari, and R. Dashti. Synthesis of calcium peroxide nanoparticles as an innovative reagent for in situ chemical oxidation. Journal of Hazardous Materials, Vol. 192, No. 3, 2011, pp. 1437–1440.10.1016/j.jhazmat.2011.06.060 ↗
22. Hu, Y., X. Wang, P. Zhao, H. Wang, W. Gu, and L. Ye. Nanozyme-catalyzed oxygen release from calcium peroxide nanoparticles for accelerated hypoxia relief and image-guided super-efficient photodynamic therapy. Biomaterials Science, Vol. 8, No. 10, 2020, pp. 2931–2938.10.1039/D0BM00187B ↗
23. Ji, C., Z. Lu, Y. Xu, B. Shen, S. Yu, and D. Shi. Self‐production of oxygen system CaO2/MnO2@ PDA‐MB for the photodynamic therapy research and switch‐control tumor cell imaging. Journal of Biomedical Materials Research, Part B: Applied Biomaterials, Vol. 106, No. 7, 2018, pp. 2544–2552.10.1002/jbm.b.34071 ↗
24. Zhang, M., T. Kiratiwongwan, and W. Shen. Oxygen‐releasing polycaprolactone/calcium peroxide composite microspheres. Journal of Biomedical Materials Research, Part B: Applied Biomaterials, Vol. 108, No. 3, 2020, pp. 1097–1106.10.1002/jbm.b.34461 ↗
25. Han, Y., J. Ouyang, Y. Li, F. Wang, and J. H. Jiang. Engineering H2O2 self-supplying nanotheranostic platform for targeted and imaging-guided chemodynamic therapy. ACS Applied Materials & Interfaces, Vol. 12, No. 1, 2020, pp. 288–297.10.1021/acsami.9b18676 ↗
26. He, C., X. Zhang, R. Yan, P. Zhao, Y. Chen, M. Li, et al. Enhancement of cisplatin efficacy by lipid–CaO2 nanocarrier-mediated comprehensive modulation of the tumor microenvironment. Biomaterials Science, Vol. 7, No. 10, 2019, pp. 4260–4272.10.1039/C9BM00797K ↗
27. Yu, Q., T. Huang, C. Liu, M. Zhao, M. Xie, G. Li, et al. Oxygen self-sufficient NIR-activatable liposomes for tumor hypoxia regulation and photodynamic therapy. Chemical Science, Vol. 10, No. 39, 2019, pp. 9091–9098.10.1039/C9SC03161H ↗
28. Zheng, A. Studies on controlled synthesis of calcium carbonate and calcium peroxide mediated by dopamine and sodium citrate and their applications. Hangzhou Normal University, Hangzhou, 2022.
29. Park, J. S., Y. J. Song, Y. G. Lim, and K. Park. Facile fabrication of oxygen-releasing tannylated calcium peroxide nanoparticles. Materials, Vol. 13, No. 17, 2020, id. 3864.10.3390/ma13173864 ↗
30. Yin, Y., T. Jiang, Y. Hao, J. Zhang, W. Li, Y. Hao, et al. Cascade catalytic nanoplatform based on ions interference strategy for calcium overload therapy and ferroptosis. International Journal of Pharmaceutics, Vol. 606, 2021, id. 120937.10.1016/j.ijpharm.2021.120937 ↗
31. Liu, L. H., Y. H. Zhang, W. X. Qiu, L. Zhang, F. Gao, B. Li, et al. Dual‐stage light amplified photodynamic therapy against hypoxic tumor based on an O2 self‐sufficient nanoplatform. Small, Vol. 13, No. 37, 2017, id. 1701621.10.1002/smll.201701621 ↗
32. Shen, S., M. Mamat, S. Zhang, J. Cao, Z. D. Hood, L. Figueroa-Cosme, et al. Synthesis of CaO2 nanocrystals and their spherical aggregates with uniform sizes for use as a biodegradable bacteriostatic agent. Small, Vol. 15, No. 36, 2019, id. e1902118.10.1002/smll.201902118 ↗
33. Ding, J., J. Chen, L. Gao, Z. Jiang, Y. Zhang, M. Li, et al. Engineered nanomedicines with enhanced tumor penetration. Nano Today, Vol. 29, 2019, id. 100800.10.1016/j.nantod.2019.100800 ↗
34. Comerford, K. M., T. J. Wallace, J. Karhausen, N. A. Louis, M. C. Montalto, and S. P. Colgan. Hypoxia-inducible factor-1-dependent regulation of the multidrug resistance (MDR1) gene. Cancer Research, Vol. 62, No. 12, 2002, pp. 3387–3394.
35. Comerford, K. M., E. P. Cummins, and C. T. Taylor. c-Jun NH2-terminal kinase activation contributes to hypoxia-inducible factor 1α–dependent P-glycoprotein expression in hypoxia. Cancer Research, Vol. 64, No. 24, 2004, pp. 9057–9061.10.1158/0008-5472.CAN-04-1919 ↗
36. Chen, J., Z. Jiang, W. Xu, T. Sun, X. Zhuang, J. Ding, et al. Spatiotemporally targeted nanomedicine overcomes hypoxia-induced drug resistance of tumor cells after disrupting neovasculature. Nano Letters, Vol. 20, No. 8, 2020, pp. 6191–6198.10.1021/acs.nanolett.0c02515 ↗
37. Yuan, J., Y. Cen, X.-J. Kong, S. Wu, C. L. Liu, R. Q. Yu, et al. MnO2-nanosheet-modified upconversion nanosystem for sensitive turn-on fluorescence detection of H2O2 and glucose in blood. ACS Applied Materials & Interfaces, Vol. 7, No. 19, 2015, pp. 10548–10555.10.1021/acsami.5b02188 ↗
38. Zhang, X., C. He, Y. Sun, X. Liu, Y. Chen, C. Chen, et al. A smart O2-generating nanocarrier optimizes drug transportation comprehensively for chemotherapy improving. Acta Pharmaceutica Sinica B, Vol. 11, No. 11, 2021, pp. 3608–3621.10.1016/j.apsb.2021.04.021 ↗
39. Zhang, X., C. He, R. Yan, Y. Chen, P. Zhao, M. Li, et al. HIF-1 dependent reversal of cisplatin resistance via anti-oxidative nano selenium for effective cancer therapy. Chemical Engineering Journal, Vol. 380, 2020, id. 122540.10.1016/j.cej.2019.122540 ↗
40. He, C., X. Zhang, C. Chen, X. Liu, Y. Chen, R. Yan, et al. A solid lipid coated calcium peroxide nanocarrier enables combined cancer chemo/chemodynamic therapy with O2/H2O2 self-sufficiency. Acta Biomaterialia, Vol. 122, 2021, pp. 354–364.10.1016/j.actbio.2020.12.036 ↗
41. Wang, Y., X. He, C. Zhou, Y. Bai, T. Li, J. Liu, et al. Nanoscale CaO2 materials for synergistic transarterial chemoembolization in a VX2 orthotopic rabbit liver cancer model. Acta Biomaterialia, Vol. 154, 2022, pp. 536–548.10.1016/j.actbio.2022.09.074 ↗
42. Zhang, F., C. Xin, Z. Dai, H. Hu, Q. An, F. Wang, et al. Oncocyte membrane-camouflaged multi-stimuli-responsive nanohybrids for synergistic amplification of tumor oxidative stresses and photothermal enhanced cancer therapy. ACS Applied Materials & Interfaces, Vol. 14, No. 36, 2022, pp. 40633–40644.10.1021/acsami.2c11200 ↗
43. Sun, Y., D. Zhao, G. Wang, Y. Wang, L. Cao, J. Sun, et al. Recent progress of hypoxia-modulated multifunctional nanomedicines to enhance photodynamic therapy: opportunities, challenges, and future development. Acta Pharmaceutica Sinica B, Vol. 10, No. 8, 2020, pp. 1382–1396.10.1016/j.apsb.2020.01.004 ↗
44. Wang, Y.-Y., Y.-C. Liu, H. Sun, and D. S. Guo. Type I photodynamic therapy by organic–inorganic hybrid materials: From strategies to applications. Coordination Chemistry Reviews, Vol. 395, 2019, pp. 46–62.10.1016/j.ccr.2019.05.016 ↗
45. Feng, G., G.-Q. Zhang, and D. Ding. Design of superior phototheranostic agents guided by Jablonski diagrams. Chemical Society Reviews, Vol. 49, No. 22, 2020, pp. 8179–8234.10.1039/D0CS00671H ↗
46. Ochsner, M. Photophysical and photobiological processes in the photodynamic therapy of tumours. Journal of Photochemistry and Photobiology, B: Biology, Vol. 39, No. 1, 1997, pp. 1–18.10.1016/S1011-1344(96)07428-3 ↗
47. Chen, D., Q. Xu, W. Wang, J. Shao, W. Huang, and X. Dong. Type I photosensitizers revitalizing photodynamic oncotherapy. Small, Vol. 17, No. 31, 2021, id. 2006742.10.1002/smll.202006742 ↗
48. Lo, P.-C., M. S. Rodríguez-Morgade, R. K. Pandey, D. Ng, T. Torres, and F. Dumoulin. The unique features and promises of phthalocyanines as advanced photosensitisers for photodynamic therapy of cancer. Chemical Society Reviews, Vol. 49, No. 4, 2020, pp. 1041–1056.10.1039/C9CS00129H ↗
49. Sun, X., K. Chen, Y. Liu, G. Zhang, M. Shi, P. Shi, et al. Metal–organic framework combined with CaO2 nanoparticles for enhanced and targeted photodynamic therapy. Nanoscale Advances, Vol. 3, No. 23, 2021, pp. 6669–6677.10.1039/D1NA00610J ↗
50. Ren, S.-Z., X.-H. Zhu, B. Wang, M. Liu, S. K. Li, Y. S. Yang, et al. A versatile nanoplatform based on multivariate porphyrinic metal–organic frameworks for catalytic cascade-enhanced photodynamic therapy. Journal of Materials Chemistry B, Vol. 9, No. 23, 2021, pp. 4678–4689.10.1039/D0TB02652B ↗
51. Gulzar, A., F. He, A. Gulzar, Y. Kuang, F. Zhang, S. Gai, et al. In situ oxygenating and 808nm light-sensitized nanocomposite for multimodal imaging and mitochondria-assisted cancer therapy. Journal of Materials Chemistry B, Vol. 9, No. 1, 2021, pp. 131–146.10.1039/D0TB01967D ↗
52. Chen, M., S. Zhao, J. Zhu, E. Feng, F. Lv, W. Chen, et al. Open-source and reduced-expenditure nanosystem with ROS self-amplification and glutathione depletion for simultaneous augmented chemodynamic/photodynamic therapy. ACS Applied Materials & Interfaces, Vol. 14, No. 18, 2022, pp. 20682–20692.10.1021/acsami.2c01782 ↗
53. Yan, J.-H., W. Meng, H. Shan, X. P. Zhang, L. M. Zou, L. L. Wang, et al. Melanin nanoparticles combined with CaO2 nanoparticles for image-guided tumor microenvironment-responsive multimodal therapy. ACS Applied Nano Materials, Vol. 4, No. 2, 2021, pp. 1351–1363.10.1021/acsanm.0c02916 ↗
54. Zhang, L., C. X. Li, S. S. Wan, and X. Z. Zhang. Nanocatalyst‐mediated chemodynamic tumor therapy. Advanced Healthcare Materials, Vol. 11, No. 2, 2022, id. 2101971.10.1002/adhm.202101971 ↗
55. Wang, X., X. Zhong, Z. Liu, and L. Cheng. Recent progress of chemodynamic therapy-induced combination cancer therapy. Nano Today, Vol. 35, 2020, id. 100946.10.1016/j.nantod.2020.100946 ↗
56. Zhang, D., Y. Meng, Y. Song, P. Cui, Z. Hu, and X. Zheng. Precision therapy through breaking the intracellular redox balance with an MOF-based hydrogel intelligent nanobot for enhancing ferroptosis and activating immunotherapy. Nanoscale, Vol. 14, No. 23, 2022, pp. 8441–8453.10.1039/D2NR00950A ↗
57. Zhou, Y., S. Fan, L. Feng, X. Huang, and X. Chen. Manipulating intratumoral fenton chemistry for enhanced chemodynamic and chemodynamic-synergized multimodal therapy. Advanced Materials, Vol. 33, No. 48, 2021, id. e2104223.10.1002/adma.202104223 ↗
58. Ruan, J., H. Liu, B. Chen, F. Wang, W. Wang, Z. Zha, et al. Interfacially engineered Zn(x)Mn(1-x)S@Polydopamine hollow nanospheres for glutathione depleting photothermally enhanced chemodynamic therapy. ACS Nano, Vol. 15, No. 7, 2021, pp. 11428–11440.10.1021/acsnano.1c01077 ↗
59. Wang, J., J. Sun, W. Hu, Y. Wang, T. Chou, B. Zhang, et al. A porous Au@Rh bimetallic core-shell nanostructure as an H2O2 -driven oxygenerator to alleviate tumor hypoxia for simultaneous bimodal imaging and enhanced photodynamic therapy. Advanced Materials, Vol. 32, No. 22, 2020, id. e2001862.10.1002/adma.202001862 ↗
60. Shi, L., F. Hu, Y. Duan, W. Wu, J. Dong, X. Meng, et al. Hybrid nanospheres to overcome hypoxia and intrinsic oxidative resistance for enhanced photodynamic therapy. ACS Nano, Vol. 14, No. 2, 2020, pp. 2183–2190.10.1021/acsnano.9b09032 ↗
61. Fan, J. X., M. Y. Peng, H. Wang, H. R. Zheng, Z. L. Liu, C. X. Li, et al. Engineered bacterial bioreactor for tumor therapy via Fenton-like reaction with localized H2O2 generation. Advanced Materials, Vol. 31, No. 16, 2019, id. e1808278.10.1002/adma.201808278 ↗
62. Feng, L., R. Xie, C. Wang, S. Gai, F. He, D. Yang, et al. Magnetic targeting, tumor microenvironment-responsive intelligent nanocatalysts for enhanced tumor ablation. ACS Nano, Vol. 12, No. 11, 2018, pp. 11000–11012.10.1021/acsnano.8b05042 ↗
63. Wu, Y., T. Guo, Y. Qiu, Y. Lin, Y. Yao, W. Lian, et al. An inorganic prodrug, tellurium nanowires with enhanced ROS generation and GSH depletion for selective cancer therapy. Chemical Science, Vol. 10, No. 29, 2019, pp. 7068–7075.10.1039/C9SC01070J ↗
64. Mamat, M., X. Wang, L. Wu, R. Zhao, J. Cao, X. Qi, et al. CaO2/Fe3O4 nanocomposites for oxygen-independent generation of radicals and cancer therapy. Colloids and Surfaces B, Biointerfaces, Vol. 204, 2021, id. 111803.10.1016/j.colsurfb.2021.111803 ↗
65. Kong, H., Q. Chu, C. Fang, G. Cao, G. Han, and X. Li. Cu-ferrocene-functionalized CaO2 nanoparticles to enable tumor-specific synergistic therapy with GSH depletion and calcium overload. Adv Sci (Weinh), Vol. 8, No. 14, 2021, id. e2100241.10.1002/advs.202100241 ↗
66. Zhang, L., S.-S. Wan, C.-X. Li, L. Xu, H. Cheng, and X. Z. Zhang. An adenosine triphosphate-responsive autocatalytic fenton nanoparticle for tumor ablation with self-supplied H2O2 and acceleration of Fe (III)/Fe (II) conversion. Nano Letters, Vol. 18, No. 12, 2018, pp. 7609–7618.10.1021/acs.nanolett.8b03178 ↗
67. Fu, L. H., Y. R. Hu, C. Qi, T. He, S. Jiang, C. Jiang, et al. Biodegradable manganese-doped calcium phosphate nanotheranostics for traceable cascade reaction-enhanced anti-tumor therapy. ACS Nano, Vol. 13, No. 12, 2019, pp. 13985–13994.10.1021/acsnano.9b05836 ↗
68. Qi, C., J. He, L. H. Fu, T. He, N. T. Blum, X. Yao, et al. Tumor-specific activatable nanocarriers with gas-generation and signal amplification capabilities for tumor theranostics. ACS Nano, Vol. 15, No. 1, 2021, pp. 1627–1639.10.1021/acsnano.0c09223 ↗
69. Dai, Y., Z. Yang, S. Cheng, Z. Wang, R. Zhang, G. Zhu, et al. Toxic reactive oxygen species enhanced synergistic combination therapy by self‐assembled metal‐phenolic network nanoparticles. Advanced Materials, Vol. 30, No. 8, 2018, id. 1704877.10.1002/adma.201704877 ↗
70. Wang, Z., B. Liu, Q. Sun, S. Dong, Y. Kuang, Y. Dong, et al. Fusiform-like copper(II)-based metal–organic framework through relief hypoxia and GSH-depletion co-enhanced starvation and chemodynamic synergetic cancer therapy. ACS Applied Materials & Interfaces, Vol. 12, No. 15, 2020, pp. 17254–17267.10.1021/acsami.0c01539 ↗
71. Ren, Z., S. Sun, R. Sun, G. Cui, L. Hong, B. Rao, et al. A metal-polyphenol-coordinated nanomedicine for synergistic cascade cancer chemotherapy and chemodynamic therapy. Advanced Materials, Vol. 32, No. 6, 2020, id. e1906024.10.1002/adma.201906024 ↗
72. Sun, P., Q. Deng, L. Kang, Y. Sun, J. Ren, and X. Qu. A smart nanoparticle-laden and remote-controlled self-destructive macrophage for enhanced chemo/chemodynamic synergistic therapy. ACS Nano, Vol. 14, No. 10, 2020, pp. 13894–13904.10.1021/acsnano.0c06290 ↗
73. Gao, S., Y. Jin, K. Ge, Z. Li, H. Liu, X. Dai, et al. Self‐supply of O2 and H2O2 by a nanocatalytic medicine to enhance combined chemo/chemodynamic therapy. Advanced Science, Vol. 6, No. 24, 2019, id. 1902137.10.1002/advs.201902137 ↗
74. Li, S., Q. Jiang, S. Liu, Y. Zhang, Y. Tian, C. Song, et al. A DNA nanorobot functions as a cancer therapeutic in response to a molecular trigger in vivo. Nature Biotechnology, Vol. 36, No. 3, 2018, pp. 258–264.10.1038/nbt.4071 ↗
75. Chen, C., W. Su, Y. Liu, J. Zhang, C. Zuo, Z. Yao, et al. Artificial anaerobic cell dormancy for tumor gaseous microenvironment regulation therapy. Biomaterials, Vol. 200, 2019, pp. 48–55.10.1016/j.biomaterials.2019.02.007 ↗
76. Zhang, X., C. He, Y. Chen, C. Chen, R. Yan, T. Fan, et al. Cyclic reactions-mediated self-supply of H2O2 and O2 for cooperative chemodynamic/starvation cancer therapy. Biomaterials, Vol. 275, 2021, id. 120987.10.1016/j.biomaterials.2021.120987 ↗
77. Liu, C., Y. Cao, Y. Cheng, D. Wang, T. Xu, L. Su, et al. An open source and reduce expenditure ROS generation strategy for chemodynamic/photodynamic synergistic therapy. Nature Communications, Vol. 11, No. 1, 2020, id. 1735.10.1038/s41467-020-15591-4 ↗
78. Xiao, Y., Z. Li, A. Bianco, and B. Ma. Recent advances in calcium‐based anticancer nanomaterials exploiting calcium overload to trigger cell apoptosis. Advanced Functional Materials, 2022, id. 2209291.10.1002/adfm.202209291 ↗
79. Giorgi, C., S. Marchi, and P. Pinton. The machineries, regulation and cellular functions of mitochondrial calcium. Nature Reviews Molecular Cell Biology, Vol. 19, No. 11, 2018, pp. 713–730.10.1038/s41580-018-0052-8 ↗
80. Zheng, P., B. Ding, Z. Jiang, W. Xu, G. Li, J. Ding, et al. Ultrasound-augmented mitochondrial calcium ion overload by calcium nanomodulator to induce immunogenic cell death. Nano Letters, Vol. 21, No. 5, 2021, pp. 2088–2093.10.1021/acs.nanolett.0c04778 ↗
81. Zheng, P. and J. Ding. Calcium ion nanomodulators for mitochondria-targeted multimodal cancer therapy. Asian Journal of Pharmaceutical Sciences, Vol. 17, No. 1, 2022, pp. 1–3.10.1016/j.ajps.2021.10.004 ↗
82. Zheng, P., B. Ding, R. Shi, Z. Jiang, W. Xu, G. Li, et al. A multichannel Ca2+ nanomodulator for multilevel mitochondrial destruction‐mediated cancer therapy. Advanced Materials, Vol. 33, No. 15, 2021, id. 2007426.10.1002/adma.202007426 ↗
83. Yang, G., Y. Liu, J. Chen, J. Ding, and X. Chen. Self-adaptive nanomaterials for rational drug delivery in cancer therapy. Accounts of Materials Research, Vol. 3, No. 12, 2022, pp. 1232–1247.10.1021/accountsmr.2c00147 ↗
84. Liu, B., S. Liang, Z. Wang, Q. Sun, F. He, S. Gai, et al. A tumor-microenvironment-responsive nanocomposite for hydrogen sulfide gas and trimodal-enhanced enzyme dynamic therapy. Advanced Materials, Vol. 33, No. 30, 2021, id. e2101223.10.1002/adma.202101223 ↗
85. Sitkovsky, M. V., S. Hatfield, R. Abbott, B. Belikoff, D. Lukashev, and A. Ohta. Hostile, hypoxia-A2-adenosinergic tumor biology as the next barrier to overcome for tumor immunologists. Cancer Immunology Research, Vol. 2, No. 7, 2014, pp. 598–605.10.1158/2326-6066.CIR-14-0075 ↗
86. An, J., K. Zhang, B. Wang, S. Wu, Y. Wang, H. Zhang, et al. Nanoenabled disruption of multiple barriers in antigen cross-presentation of dendritic cells via calcium interference for enhanced chemo-immunotherapy. ACS Nano, Vol. 14, No. 6, 2020, pp. 7639–7650.10.1021/acsnano.0c03881 ↗
87. Bong, A. H. L. and G. R. Monteith. Calcium signaling and the therapeutic targeting of cancer cells. Biochimica et Biophysica Acta, Molecular Cell Research, Vol. 1865, No. 11 Pt B, 2018, pp. 1786–1794.10.1016/j.bbamcr.2018.05.015 ↗
88. Peters, A. A., M. J. Milevskiy, W. C. Lee, M. C. Curry, C. E. Smart, J. M. Saunus, et al. The calcium pump plasma membrane Ca2+-ATPase 2 (PMCA2) regulates breast cancer cell proliferation and sensitivity to doxorubicin. Scientific Reports, Vol. 6, 2016, id. 25505.10.1038/srep25505 ↗
89. Seo, J. A., B. Kim, D. N. Dhanasekaran, B. K. Tsang, and Y. S. Song. Curcumin induces apoptosis by inhibiting sarco/endoplasmic reticulum Ca2+ ATPase activity in ovarian cancer cells. Cancer Letters, Vol. 371, No. 1, 2016, pp. 30–37.10.1016/j.canlet.2015.11.021 ↗
90. Doskey, C. M., V. Buranasudja, B. A. Wagner, J. G. Wilkes, J. Du, J. J. Cullen, et al. Tumor cells have decreased ability to metabolize H2O2: Implications for pharmacological ascorbate in cancer therapy. Redox Biology, Vol. 10, 2016, pp. 274–284.10.1016/j.redox.2016.10.010 ↗
91. Ermak, G. and K. J. Davies. Calcium and oxidative stress: from cell signaling to cell death. Molecular Immunology, Vol. 38, No. 10, 2002, pp. 713–721.10.1016/S0161-5890(01)00108-0 ↗
92. Jiang, Y., W. Meng, L. Wu, K. Shao, L. Wang, M. Ding, et al. Image-guided TME-improving nano-platform for Ca2+ signal disturbance and enhanced tumor PDT. Advanced Healthcare Materials, Vol. 10, No. 19, 2021, id. e2100789.10.1002/adhm.202100789 ↗
93. Chen, F., B. Yang, L. Xu, J. Yang, and J. Li. A CaO2@Tannic Acid‐FeIII nanoconjugate for enhanced chemodynamic tumor therapy. ChemMedChem, Vol. 16, No. 14, 2021, pp. 2278–2286.10.1002/cmdc.202100108 ↗
94. Qian, G., J. Wang, L. Yang, Z. Zeng, Z. Zhao, S. Peng, et al. A pH-responsive CaO2@ZIF-67 system endows a scaffold with chemodynamic therapy properties. Journal of Materials Science, Vol. 58, 2023, pp. 1–5.10.1007/s10853-022-08103-w ↗
95. Cheng, F. Y., C. H. Chan, B. J. Wang, Y. L. Yeh, Y. J. Wang, and H. W. Chiu. The oxygen-generating calcium peroxide-modified magnetic nanoparticles attenuate hypoxia-induced chemoresistance in triple-negative breast cancer. Cancers (Basel), Vol. 13, No. 4, 2021, id. 606.10.3390/cancers13040606 ↗
96. Ruan, L., G. Song, X. Zhang, T. Liu, Y. Sun, J. Zhu, et al. Transdermal delivery of multifunctional CaO2@Mn-PDA nanoformulations by microneedles for NIR-induced synergistic therapy against skin melanoma. Biomaterials Science, Vol. 9, No. 20, 2021, pp. 6830–6841.10.1039/D1BM01117K ↗
97. Suo, M., Z. Liu, W. Tang, J. Guo, W. Jiang, Y. Liu, et al. Development of a novel oxidative stress-amplifying nanocomposite capable of supplying intratumoral H2O2 and O(2) for enhanced chemodynamic therapy and radiotherapy in patient-derived xenograft (PDX) models. Nanoscale, Vol. 12, No. 45, 2020, pp. 23259–23265.10.1039/D0NR06594C ↗
98. Cui, R., J. Shi, and Z. Liu. Metal-organic framework-encapsulated nanoparticles for synergetic chemo/chemodynamic therapy with targeted H2O2 self-supply. Dalton Transactions, Vol. 50, No. 43, 2021, pp. 15870–15877.10.1039/D1DT03110D ↗
99. Yang, P., Y. Chang, J. Zhang, F. Gao, X. Liu, Q. Wei, et al. The combination of in situ photodynamic promotion and ion-interference to improve the efficacy of cancer therapy. Journal of Colloid and Interface Science, Vol. 629, 2023, pp. 522–533.10.1016/j.jcis.2022.08.125 ↗
100. Kong, H., C. Fang, Q. Chu, Z. Hu, Y. Fu, G. Han, et al. Catalytic core-shell nanoparticles with self-supplied calcium and H2O2) to enable combinational tumor inhibition. Journal of Nanobiotechnology, Vol. 19, No. 1, 2021, id. 313.10.1186/s12951-021-01055-4 ↗