A novel biomimetic trabecular bone metal plate for bone repair and osseointegration
Source abstract
Abstract
Abstract Fracture is one of the most common traumatic diseases in clinical practice, and metal plates have always been the first choice for fracture treatment because of their high strength. However, the bone plates have high elastic modulus and do not match the biomechanics of human bone, which adversely affects callus formation and fracture healing. Moreover, the complex microenvironment in the human body can induce corrosion of metallic materials and release toxic ions, which reduces the biocompatibility of the bone plate, and may necessitate surgical removal of the implant. In this study, tantalum (Ta) was deposited on porous silicon carbide (SiC) scaffolds by chemical vapor deposition technology to prepare a novel porous tantalum (pTa) trabecular bone metal plate. The function of the novel bone plate was evaluated by implantation in an animal fracture model. The results showed that the novel bone plate was effective in fracture fixation, without breakage. Both X-ray and microcomputed tomography analysis showed indirect healing by both pTa trabecular bone metal plates and titanium (Ti) plates; however, elastic fixation and obvious callus formation were observed after fixation with pTa trabecular bone metal plates, indicating better bone repair. Histology showed that pTa promoted the formation of new bone and integrated well with the host bone. Therefore, this novel pTa trabecular bone metal plate has good prospects for application in treating fractures.
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Research context
OpenAlex topics: Bone Tissue Engineering Materials · Titanium Alloys Microstructure and Properties · Orthopaedic implants and arthroplasty
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Orthopaedic of Department, Affiliated ZhongShan Hospital of Dalian University , Dalian, Liaoning 116001, China
Orthopaedic of Department, The Fourth People's Hospital of Guiyang , Guiyang, Guizhou 550000, China
School of Biomedical Engineering, Faculty of Electronic Information and Electrical Engineering, Dalian University of Technology , Dalian, Liaoning 116024, China
Funding
National Natural Science Foundation of China · Dalian Medical Key Specialty ‘Dengfeng Plan’ Construction Project · China Postdoctoral Science Foundation
References (30)
Show source-provided references
1. Some remarks on the treatment of fractures10.1136/bmj.1.1790.861 ↗
2. Bone Plate composed of a ternary nanohydroxyapatite/polyamide 66/glass fiber composite: biocompatibility in vivo and internal fixation for canine femur fractures10.1002/adfm.201808738 ↗
3. Titanium fiber plates for bone tissue repair10.1002/adma.201703608 ↗
4. Fabrication of the porous tantalum and its current status used as orthopedics implants materials
5. Topological design and additive manufacturing of porous metals for bone scaffolds and orthopaedic implants: a review10.1016/j.biomaterials.2016.01.012 ↗
6. 3D-printed bioceramic scaffolds: from bone tissue engineering to tumor therapy10.1016/j.actbio.2018.08.026 ↗
7. Experimental study of a 3D printed permanent implantable porous ta-coated bone plate for fracture fixation10.1016/j.bioactmat.2021.09.009 ↗
8. Additive-manufactured Ti-6Al-4 V/polyetheretherketone composite porous cage for interbody fusion: bone growth and biocompatibility evaluation in a porcine model10.1186/s12891-021-04022-0 ↗
9. Mechanical design optimization of bioabsorbable fixation devices for bone fractures10.1097/SCS.0b013e31819b96fb ↗
10. The Clinical feasibility of newly developed thin flat-type bioresorbable osteosynthesis devices for the internal fixation of zygomatic fractures: is there a difference in healing between bioresorbable materials and titanium osteosynthesis?10.1097/SCS.0000000000003147 ↗
11. Overview of innovative advances in bioresorbable plate systems for oral and maxillofacial surgery10.1016/j.jdsr.2018.03.003 ↗
12. Materials evolution of bone plates for internal fixation of bone fractures: a review10.1016/j.jmst.2019.07.024 ↗
13. Comparison of porous tantalum acetabular implants and Harrington reconstruction for metastatic disease of the acetabulum10.2106/JBJS.19.01189 ↗
14. Reconstruction of acetabular defects with porous tantalum shells and augments in revision total hip arthroplasty at ten-year follow-up
15. Clinical Survivorship of aseptic revision total knee arthroplasty using hinged knees and tantalum cones at minimum 10-year follow-up10.1016/j.arth.2019.06.057 ↗
16. Porous silicon carbide coated with tantalum as potential material for bone implants10.1093/rb/rbaa021 ↗
17. Bone screws of porous silicon carbide coated with tantalum improve osseointegration and osteogenesis in goat femoral neck fractures10.1088/1748-605X/ac103b ↗
18. A novel tantalum coating on porous SiC used for bone filling material10.1016/j.matlet.2016.05.065 ↗
19. AO philosophy and principles of fracture management-its evolution and evaluation10.2106/00004623-200306000-00029 ↗
20. Review on titanium and titanium based alloys as biomaterials for orthopaedic applications10.1016/j.msec.2019.04.064 ↗
21. The relationship between stress shielding and bone resorption around total hip stems and the effects of flexible materials10.1097/00003086-199201000-00014 ↗
22. Evaluation of bone plate with low-stiffness material in terms of stress distribution10.1016/j.jbiomech.2008.08.003 ↗
23. Evolution of the internal fixation of long bone fractures. The scientific basis of biological internal fixation: choosing a new balance between stability and biology10.1302/0301-620X.84B8.0841093 ↗
24. Magnesium and its alloys as orthopedic biomaterials: a review10.1016/j.biomaterials.2005.10.003 ↗
25. History of internal fixation with plates (part 2): new developments after world war II; compressing plates and locked plates10.1007/s00264-016-3379-9 ↗
26. Effects and mechanisms of mechanical stress on secondary fracture healing10.2741/4183 ↗
27. Biomedical titanium alloys with young's moduli close to that of cortical bone10.1093/rb/rbw016 ↗
28. Development of new metallic alloys for biomedical applications10.1016/j.actbio.2012.06.037 ↗
29. Balance between mechanical stability and mechano-biology of fracture healing under volar locking plate10.1007/s10439-021-02815-x ↗
30. The biology of fracture healing10.1016/j.injury.2011.03.031 ↗