DataVXCellulose Chemistry and TechnologyPaper
journal article·2019-08-28Open access

NOVEL CATIONIC AND HYDROPHOBIC PULLULAN DERIVATIVES AS DNA NANOPARTICULATE CARRIERS

Department of Natural Polymers, Bioactive and Biocompatible Materials, “Petru Poni” Institute of Macromolecular Chemistry, 41A, Gr. Ghica Voda Alley, 700487 Iasi, Romania, MARIETA CONSTANTIN, SANDA BUCATARIU, Department of Natural Polymers, Bioactive and Biocompatible Materials, “Petru Poni” Institute of Macromolecular Chemistry, 41A, Gr. Ghica Voda Alley, 700487 Iasi, Romania, LAURA URSU, Centre of Advanced Research in Bionanoconjugates and Biopolymers, “Petru Poni” Institute of Macromolecular Chemistry, 41A, Gr. Ghica Voda Alley, 700487 Iasi, Romania, MARIA BUTNARU, Faculty of Medical Bioengineering, “Gr. T. Popa” University of Medicine and Pharmacy, 16, University Str., 700115 Iasi, Romania, OANA MARIA DARABA, Domenico Medical Center SRL, 11 Pacurari Str., 700511 Iasi, Romania, ALEXANDRA MARIA BURLUI, Domenico Medical Center SRL, 11 Pacurari Str., 700511 Iasi, Romania, GHEORGHE FUNDUEANU, Department of Natural Polymers, Bioactive and Biocompatible Materials, “Petru Poni” Institute of Macromolecular Chemistry, 41A, Gr. Ghica Voda Alley, 700487 Iasi, Romania

Cellulose Chemistry and Technology· Volume 53· Issue 7-8
Publisher pageOpen full text
Source abstract

Abstract

A novel cationic associating pullulan derivative (DBAP-P) was synthesized using pullulan as hydrophilic backbone and (dibuthylamino)propyl carbamate groups as pendant cationic and hydrophobic segments. The structural characteristics of this polymer were investigated by FT-IR, 1 H-and 13 C-NMR spectroscopy. The degree of substitution was found to be 0.36 cationic moieties per structural unit of pullulan. The intrinsic viscosity of the DBAP-P sample was calculated using Fedors' and Wolf's models. The critical aggregation concentration (cac) value of 0.1 g/dL determined by fluorescence measurements in the presence of pyrene, as probe, was confirmed by capillary viscosimetry and dynamic laser scattering (DLS). DNA was loaded into the DBAP-P particles by the osmosis based method. The mean diameter and zeta potential of DNA-loaded particles in aqueous solutions, as determined by DLS, decreased with increasing the DNA/DBAP-P ratio for the same polymer concentration. AFM images demonstrated that the DBAP-P and DNA-loaded DBAP-P nanoparticles had a spherical shape.
Source: openalex_inverted_index · Quality: baseline

Research context

PolymersNanomaterials

OpenAlex topics: Polysaccharides Composition and Applications · biodegradable polymer synthesis and properties · Polymer Surface Interaction Studies

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

References

Reference metadata was not supplied for this record.