DESIGN OF JACKFRUIT GUM-BASED GENIPIN CROSSLINKED NANOPARTICLES FOR SUSTAINED RELEASE OF CURCUMIN: OPTIMIZATION AND IN VITRO CHARACTERIZATION

Department of Pharmaceutics, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur 425 405, Maharashtra, India; SWAPNIL THAKARE; ASHISH GORLE; Department of Pharmaceutics, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur 425 405, Maharashtra, India

doi:10.35812/cellulosechemtechnol.2024.58.07

journal article·2024-03-15Open access

DESIGN OF JACKFRUIT GUM-BASED GENIPIN CROSSLINKED NANOPARTICLES FOR SUSTAINED RELEASE OF CURCUMIN: OPTIMIZATION AND IN VITRO CHARACTERIZATION

Department of Pharmaceutics, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur 425 405, Maharashtra, India, SWAPNIL THAKARE, ASHISH GORLE, Department of Pharmaceutics, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur 425 405, Maharashtra, India

Cellulose Chemistry and Technology· Volume 58· Issue 1-2

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Source abstract

Abstract

The present work aims to design jackfruit gum-based curcumin-loaded nanoparticles (CUR-NPs) for improved drug entrapment and modified release of CUR using ionotropic gelation. Briefly, the optimization of CUR-NPs was confirmed using a 32 response surface methodology. The diffractogram and thermogram of CUR-NPs confirmed reduction of crystallinity of CUR (optimized batch: F5) due to jackfruit gum and genipin cross-linked polymeric network. The particle size and zeta potential analysis confirmed formation of nanosized and stable CUR-NPs, respectively. Also, the nanoparticles demonstrated 83.99 ± 1.23% entrapment efficiency, whereas they showed 98.36 ± 0.96% of CUR release within 12 h at pH 7.4. The CUR-NPs exhibited good mucoadhesive properties due to the presence of jackfruit gum. Finally, the MTT assay showed a decrease in colorectal cancer cell viability due to tailored CUR release from CUR-NPs. In conclusion, jackfruit gum-genipin-based CUR-NPs offered high entrapment efficiency, tailored releases of CUR, good mucoadhesive property and improved anticancer activity.

Source: crossref · Quality: baseline

Research context

Polymers Nanomaterials

OpenAlex topics: Advanced Drug Delivery Systems · Curcumin's Biomedical Applications · Nanoparticle-Based Drug Delivery

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

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