Chemical and biological characterization of sulfated chitosan oligomer as heparin mimics
Source abstract
Abstract
In the present study, chitosan oligomer was modified to sulfated chitosan oligomer (ShCsO) to mimic heparin. Its chemical structure was determined by infrared spectroscopy (FT-IR), X-ray diffractometry (XRD), differential scanning calorimetry (DSC), and thermogravimetric analysis. The results showed that the FT-IR spectrum band at 799 cm −1 corresponds to C–O–S and that at 1212 cm −1 corresponds to S=O bond stretching, which prove that the sulfate groups are incorporated into chitosan oligomer successfully. The antimicrobial activity of ShCsO against to Bacillus subtilis in 1% concentration was 89.1 ± 1.7% . The IC50 (μg/ml) of ShCsO was 67.75, 56.07, 85.47, and 84.68 for A2780, MCF-7, DU-145, and HepG2, respectively. The results show that this newly synthesized material is a potential candidate to heparin-like chitosan derivatives. According to the literature, it was the first time that chitosan oligomer was modified to mimic heparin.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Nanocomposite Films for Food Packaging · Antimicrobial agents and applications · Silk-based biomaterials and applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Science Faculty, Department of Molecular Biology and Genetics, Cumhuriyet University, Sivas, Turkey
Science and Literature Faculty, Department of Molecular Biology and Genetics, Inonu University, Malatya, Turkey
Department of Nutrition and Dietetics, Osmaniye Ata Korkut University, Osmaniye, Turkey
Faculty of Medicine, Department of Physiology, Inonu University, Malatya, Turkey
School of Medicine, Department of Biophysics, Cumhuriyet University, Sivas, Turkey
Funding
Cumhuriyet University Scientific Research Project (CUBAP) financed this project
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