Chitosan-based hydrogels prepared by UV polymerization for wound dressing
Source abstract
Abstract
Chitosan-based hydrogels were prepared by grafting with poly(acrylic acid) (PAA) and poly(hydroxyethyl methacrylate) (pHEMA) through ultraviolet polymerization to further improve its hydrophilic nature and enhance its mechanical properties. The epidermal growth factor (EGF) was incorporated inside the hydrogels to stimulate the wound healing. The physical characterization of chitosan-PAA-pHEMA hydrogel indicates that it is highly hydrophilic with adequate properties for wound dressing purpose. The biological characterization shows that chitosan-based hydrogel retains its thrombogenic and antibacterial properties. The in vivo wound healing experiment demonstrates that the hydrogel-incorporated EGF has better wound healing rate than other dressings.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Wound Healing and Treatments · Surgical Sutures and Adhesives · Antimicrobial agents and applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Anesthesiology, Taipei Medical University-Wan Fang Hospital, Taipei, Taiwan
Department of Chemical and Materials Engineering, Southern Taiwan University of Science and Technology, Tainan, Taiwan
Department of Nursing, Chung Hwa University of Medical Technology, Tainan, Taiwan
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