Chitosan-Functionalized Methacrylate Monoliths for Mixed-Mode Hydrophilic/Electrostatic Interaction Capillary Liquid Chromatography
Source abstract
Abstract
Chitosan stands as a sustainable, active, and eco-friendly biomass that meets eight aspects of green chemistry principles. The chitosan-based liquid chromatography stationary phase provides superior physiochemical properties including a cationic hydrophilic surface, porosity, and mechanical strength; however, it lacks solubility in an organic solvent. A low-cost one-pot in situ free radical polymerization strategy was used to fabricate chitosan-functionalized methacrylate monolithic columns (Ch-GMA- co -EDMA) with hydrophilic and electrostatic properties. The polymerization mixtures were systematically optimized using mixture design to study the effects of compositions on flow-through processes involving porosity and permeability. The chitosan-functionalized methacrylate monomer and monolithic columns were characterized by using ATR-FTIR, TGA, DGA, and SEM. The obtained columns provide high chromatographic performance and satisfactory selectivity for organic polar, neutral, and charged compounds such as phenols, nucleic bases, nucleosides, and anionic pesticides. The results revealed that the amino and hydroxyl moieties of the chitosan monoliths functioned for both hydrophilic as well as electrostatic trapping of polar compounds, additionally promoting hydrogen bonding interaction with the analytes.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Analytical Chemistry and Chromatography · Microfluidic and Capillary Electrophoresis Applications · Innovative Microfluidic and Catalytic Techniques Innovation
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Pesticide Chemistry and Technology, Faculty of Agriculture, Alexandria University, 21545 El-Shatby, Alexandria, Egypt
Unit of Analysis and Scientific Services (Central Lab), Faculty of Agriculture, Alexandria University, 21545 El-Shatby, Alexandria, Egypt
Egypt-Japan University of Science and Technology, Alexandria, 21934 Borg El Arab, Egypt
Department of Engineering Science, Graduate School of Engineering, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan
Department of Life Science and Chemistry, Graduate School of Natural Science and Technology, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan
Department of Chemistry and Biomolecular Science, Faculty of Engineering, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan
International Joint Department of Materials Science and Engineering between National University of Malaysia and Gifu University, Graduate School of Engineering, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan
Funding
Japan Society for the Promotion of Science
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